About: Alglucerase

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About: Alglucerase Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Human Beta-glucocerebrosidase or Beta-D-glucosyl-N-acylsphingosine glucohydrolase E.C. 3.2.1.45. 497 residue protein with N-linked carbohydrates, MW=59.3 kD. Alglucerase is prepared by modification of the oligosaccharide chains of human Beta-glucocerebrosidase. The modification alters the sugar residues at the non-reducing ends of the oligosaccharide chains of the glycoprotein so that they are predominantly terminated with mannose residues (en)
http://linked.open...generalReferences	# Grabowski GA, Kacena K, Cole JA, Hollak CE, Zhang L, Yee J, Mistry PK, Zimran A, Charrow J, vom Dahl S: Dose-response relationships for enzyme replacement therapy with imiglucerase/alglucerase in patients with Gaucher disease type 1. Genet Med. 2009 Feb;11(2):92-100. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/19265748 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	3.6-10.4 min (en)
http://linked.open...ugbank/indication	For the treatment of Gaucher's disease (deficiency in glucocerebrosidase) (en)
http://linked.open...bank/manufacturer	Genzyme corp
sameAs	Alglucerase Alglucerase
Title	Alglucerase (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00088/identifier/drugbank/DB00088 http://linked.opendata.cz/resource/drugbank/drug/DB00088/identifier/genbank/M16328 http://linked.opendata.cz/resource/drugbank/drug/DB00088/identifier/kegg-drug/D09675 http://linked.opendata.cz/resource/drugbank/drug/DB00088/identifier/national-drug-code-directory/58468-1060-1 http://linked.opendata.cz/resource/drugbank/drug/DB00088/identifier/uniprotkb/P04062 http://linked.opendata.cz/resource/drugbank/drug/DB00088/identifier/pharmgkb/PA164748093 http://linked.opendata.cz/resource/drugbank/drug/DB00088/identifier/wikipedia/Alglucerase
http://linked.open...mechanismOfAction	Alglucerase catalyzes the hydrolysis of the glycolipid, glucocerebroside, to glucose and ceramide as part of the normal degradation pathway for membrane lipids. (en)
http://linked.open...drugbank/packager	Cardinal Health Genzyme Inc. Oso Biopharmaceuticals Manufacturing LLC
http://linked.open...umeOfDistribution	* 49.4 to 282.1 mL/kg (en)
foaf:page	http://www.drugs.com/cdi/alglucerase.html http://www.rxlist.com/cgi/generic3/ceredase.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4431-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4430-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Alglucerase
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	37228-64-1 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Ceredase 80 unit/ml vial
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B442E-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B442F-363D-11E5-9242-09173F13E4C5

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