About: Alemtuzumab

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein,CD52. The Campath-1H antibody is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody (Campath-1G). Campath is produced in mammalian cell (Chinese hamster ovary) suspension culture in a medium containing neomycin. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4420-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4421-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4422-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4423-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Hale G, Bright S, Chumbley G, Hoang T, Metcalf D, Munro AJ, Waldmann H: Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement. Blood. 1983 Oct;62(4):873-82. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6349718 # Riechmann L, Clark M, Waldmann H, Winter G: Reshaping human antibodies for therapy. Nature. 1988 Mar 24;332(6162):323-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/3127726 # IGMT "Link":http://imgt.cines.fr/3Dstructure-DB/cgi/details.cgi?pdbcode=1BEY # IGMT "Link":http://imgt.cines.fr/3Dstructure-DB/cgi/details.cgi?pdbcode=1CE1 # IGMT "Link":http://imgt.cines.fr/3Dstructure-DB/cgi/details.cgi?pdbcode=8005 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	~288 hrs (en)
http://linked.open...ugbank/indication	Alemtuzumab (Campath) is a monoclonal antibody therapy used for treatment of B-cell chronic lymphocytic leukemia. (en)
sameAs	Alemtuzumab Alemtuzumab
Title	Alemtuzumab (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00087/identifier/drugbank/DB00087 http://linked.opendata.cz/resource/drugbank/drug/DB00087/identifier/national-drug-code-directory/50419-357-03 http://linked.opendata.cz/resource/drugbank/drug/DB00087/identifier/pharmgkb/PA164783958 http://linked.opendata.cz/resource/drugbank/drug/DB00087/identifier/wikipedia/Alemtuzumab
http://linked.open...mechanismOfAction	Campath binds to the CD52 antigen present on most B and T lymphocytes. This binding leads to antibody-dependent lysis of leukemic cells. (en)
http://linked.open...drugbank/packager	Akorn Inc. APP Pharmaceuticals A-S Medication Solutions LLC B&B Pharmaceuticals
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/1339198
http://linked.open...umeOfDistribution	* 0.18 L/kg (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/10-00-00
foaf:page	http://www.drugs.com/cdi/alemtuzumab.html http://www.rxlist.com/cgi/generic/campath.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4428-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4427-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	http://linked.opendata.cz/resource/atc/L04AA34
http://linked.open...casRegistryNumber	216503-57-0 (en)
http://linked.open...gbank/containedIn	Apo-Pindol 5 mg Tablet Desoximetasone 0.25% cream
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B4425-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B4426-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B4424-363D-11E5-9242-09173F13E4C5

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