About: Streptokinase

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For the treatment of acute evolving transmural myocardial infarction, pulmonary embolism, deep vein thrombosis, arterial thrombosis or emolism and occlusion of arteriovenous cannulae (en)
sameAs	Streptokinase Streptokinase
Title	Streptokinase (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00086/identifier/drugbank/DB00086 http://linked.opendata.cz/resource/drugbank/drug/DB00086/identifier/genbank/K02986 http://linked.opendata.cz/resource/drugbank/drug/DB00086/identifier/uniprotkb/P00779 http://linked.opendata.cz/resource/drugbank/drug/DB00086/identifier/pharmgkb/PA164754919 http://linked.opendata.cz/resource/drugbank/drug/DB00086/identifier/wikipedia/Streptokinase
http://linked.open...mechanismOfAction	Plasminogen is an inactive molecule that becomes activated to plasmin when the Arg/Val bond is cleaved. Plasmin breaks down fibrin clots created by the blood clotting cascade. Streptokinase forms a highly specific 1:1 enzymatic complex with plasminogen which converts inactive plasminogen molecules into active plasmin. Plasmin degrades fibrin clots as well as fibrinogen and other plasma proteins. This in turn leads to the degradation of blood clots. (en)
http://linked.open...drugbank/packager	Pfizer Inc.
http://linked.open.../drugbank/synonym	Streptokinase C precursor (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/20-12-20
http://linked.open...ynthesisReference	Lawrence Isaac Galler, "Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy." U.S. Patent US6087332, issued July, 1997. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0020580
foaf:page	http://www.drugs.com/cons/streptokinase-intravenous-intracoronary.html http://www.rxlist.com/cgi/generic2/streptokinase.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4419-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4418-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Streptokinase
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	9002-01-1 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B4416-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B4417-363D-11E5-9242-09173F13E4C5

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