| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - Pancrelipase is an enzyme mixture isolated from porcine or bovine pancreas, sometimes called pancreatin. It contains 3 enzymes: amylase, lipase, and a protease (chymotrypsin). Pancrelipase is marketed under several brand names such as Ultresa™ and Viokace™. (en)
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| http://linked.open...y/drugbank/dosage
| |
| http://linked.open...gy/drugbank/group
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| http://linked.open...drugbank/halfLife
| - Pancrelipase is not significantly absorbed from the gastrointestinal tract and acts locally, so there is no terminal elimination half life. (en)
|
| http://linked.open...ugbank/indication
| - For treatment of exocrine pancreatic insufficiency in cystic fibrosis (Ultresa™), chronic pancreatitis (Viokace™ in combination with a proton pump inhibitor), and pancreatectomy (Viokace™ in combination with a proton pump inhibitor). (en)
|
| sameAs
| |
| Title
| |
| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - The lipase, protease and amylase components of pancrelipase break down fat, protein, and starches, respectively, in the small intestine. Lipase hydrolyzes fats into glycerol and fatty acids. Protease converts proteins into proteoses and derived substances, while amylase converts starches into dextrins and sugars. (en)
|
| http://linked.open...drugbank/packager
| |
| http://linked.open...outeOfElimination
| - Pancrelipase is eliminated in the feces. (en)
|
| http://linked.open.../drugbank/synonym
| - 1,4-alpha-D- glucan glucanohydrolase (en)
- PA (en)
- Pancreatic alpha-amylase precursor (en)
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| http://linked.open...drugbank/toxicity
| - Overdose symptoms may include diarrhea or stomach upset. The most common adverse reactions seen are ear, neck, and abdominal pain; headache, nasal congestion, and beta-hemolytic streptococcal infection. (en)
|
| http://linked.open...umeOfDistribution
| - Pancrelipase acts locally, so there is no volume of distribution. (en)
|
| http://linked.open...k/foodInteraction
| - Multivitamins/minerals which have vitamins ADEK, folate, or iron: If pancrelipase is used in combination with multivitamins/minerals that have vitamins ADEK, folate, or iron then monitor therapy because pancrelipase may decrease absorption of iron in these multivitamin/mineral products. (en)
- Take pancrelipase with meals and a sufficient amount of water. (en)
- Delayed release capsules should not be broken or crushed, but for those patients who cannot swallow the capsules, sprinkle the contents of the capsule onto soft acidic foods (pH of ≤4.5). Alkaline foods with a higher pH will promote early release of pancrelipase followed by enzyme inactivation in the stomach. (en)
|
| http://linked.open...nk/proteinBinding
| - Pancrelipase acts locally, so there is minimal plasma protein binding. (en)
|
| http://linked.open...y/mesh/hasConcept
| |
| foaf:page
| |
| http://linked.open...Molecular-Formula
| |
| http://linked.open.../Molecular-Weight
| |
| http://linked.open...ugbank/absorption
| - Pancrelipase is not significantly absorbed from the gastrointestinal tract. (en)
|
| http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
|
| http://linked.open...casRegistryNumber
| |
| http://linked.open...drugbank/category
| |
| http://linked.open...rugbank/clearance
| - Pancrelipase is not significantly absorbed, so there is minimal clearance from the body. (en)
|
| http://linked.open...gbank/containedIn
| |
| http://linked.open...Isoelectric-Point
| |
| http://linked.open...ank/Melting-Point
| |
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