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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • 0.8 hours (mammalian reticulocytes, in vitro) (en)
http://linked.open...ugbank/indication
  • For treatment of non-Hodgkin's lymphoma (CD20 positive, follicular) (en)
sameAs
Title
  • Tositumomab (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Binds to the CD20 antigen which is found on mature B lymphocytes. The antibody binding appears to induce apoptosis, complement-dependent cytotoxicity and cell death through ionizing radiation. (en)
http://linked.open...drugbank/packager
http://linked.open...outeOfElimination
  • Elimination of Iodine-131 occurs by decay and excretion in the urine. (en)
http://linked.open.../drugbank/synonym
  • Ig gamma-1 chain C region (en)
http://linked.open.../drug/hasAHFSCode
foaf:page
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 192391-48-3 (en)
http://linked.open...rugbank/clearance
  • * 68.2 mg/hr [patients with NHL] (en)
http://linked.open...gbank/containedIn
http://linked.open...nk/Hydrophobicity
http://linked.open...Isoelectric-Point
http://linked.open...ank/Melting-Point
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