About: Ibritumomab

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Indium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light chains of 213 amino acids each. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4397-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	#American Society of Health System Pharmacists, Inc., DynaMed [Internet]. Ipswich (MA): EBSCO Information Services. 1995. Ibritumomab; [updated 2013 Jan 18; cited 2014 Nov 24]. Available from http://web.b.ebscohost.com/dynamed/detail?vid=6&sid=48a6db20-234e-4280-b18e-dcd0e2fed388%40sessionmgr198&hid=102&bdata=JnNpdGU9ZHluYW1lZC1saXZlJnNjb3BlPXNpdGU%3d#db=dme&AN=232878 #Lexicomp Online (2014). Ibritumomab. Available at:http://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/7065#f_pharmacology-and-pharmacokinetics [Accessed 24 Nov. 2014]. (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	0.8 hours (mammalian reticulocytes, in vitro) (en)
http://linked.open...ugbank/indication	For treatment of non-Hodgkin's lymphoma (en)
sameAs	Ibritumomab Ibritumomab
Title	Ibritumomab (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00078/identifier/drugbank/DB00078 http://linked.opendata.cz/resource/drugbank/drug/DB00078/identifier/genbank/J00470 http://linked.opendata.cz/resource/drugbank/drug/DB00078/identifier/uniprotkb/P01865 http://linked.opendata.cz/resource/drugbank/drug/DB00078/identifier/pharmgkb/PA164781375 http://linked.opendata.cz/resource/drugbank/drug/DB00078/identifier/wikipedia/Ibritumomab
http://linked.open...mechanismOfAction	The Fab segment of the antibody targets the CD20 epitope on B-cells, allowing the radioactive yttrium to destroy the cell via production of beta particles. (en)
http://linked.open...drugbank/packager	Bedford Labs
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/2149329
http://linked.open.../drugbank/synonym	Ig gamma-2A chain C region, membrane-bound form (en) radiolabeled murine anti-CD20 (en)
http://linked.open...umeOfDistribution	Binding observed on lymphoid cells of the bone marrow, lymph node, thymus, red and white pulp of the spleen, lymphoid follicles of the tonsil, and lymphoid nodules of other organs (e.g., large and small intestines) (en)
foaf:page	http://www.drugs.com/cdi/ibritumomab-tiuxetan-with-indium-111.html http://www.rxlist.com/cgi/generic3/zevalin.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B439C-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B439B-363D-11E5-9242-09173F13E4C5
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	174722-31-7 (en)
http://linked.open...rugbank/clearance	Approximately 7.2% of injected dose of yttrium Y 90 ibritumomab tiuxetan is excreted in urine within 7 days. (en)
http://linked.open...gbank/containedIn	Zevalin in-111 kit Zevalin y-90 kit
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B4399-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B439A-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B4398-363D-11E5-9242-09173F13E4C5

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