About: Muromonab

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a). (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4384-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	0.8 hours (mammalian reticulocytes, in vitro) (en)
http://linked.open...ugbank/indication	For treatment of organ transplant recipients, prevention of organ rejection (en)
sameAs	Muromonab Muromonab
Title	Muromonab (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00075/identifier/drugbank/DB00075 http://linked.opendata.cz/resource/drugbank/drug/DB00075/identifier/kegg-drug/D05092 http://linked.opendata.cz/resource/drugbank/drug/DB00075/identifier/national-drug-code-directory/59676-101-01 http://linked.opendata.cz/resource/drugbank/drug/DB00075/identifier/pharmgkb/PA164743097 http://linked.opendata.cz/resource/drugbank/drug/DB00075/identifier/wikipedia/Muromonab
http://linked.open...mechanismOfAction	Muromonab binds to the T-cell surface glycoprotein CD3 epsilon chain. It appears to kill CD-3 positive cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity. (en)
http://linked.open...drugbank/packager	Centocor Ortho Biotech Inc.
http://linked.open.../drugbank/synonym	Muromonab-CD3 (en) Anti-CD3 (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/92-00-00
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4389-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4388-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Muromonab-CD3
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	140608-64-6 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Orthoclone okt-3 5 mg/5 ml
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B4386-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B4387-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B4385-363D-11E5-9242-09173F13E4C5

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