About: Basiliximab     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell line genetically engineered to express plasmids containing the human heavy and light chain constant region genes and mouse heavy and light chain variable region genes encoding the RFT5 antibody that binds selectively to the IL-2R alpha. (en)
http://linked.open...y/drugbank/dosage
http://linked.open...gy/drugbank/group
  • approved (en)
  • investigational (en)
http://linked.open...drugbank/halfLife
  • 7.2 +/- 3.2 days (adults) (en)
http://linked.open...ugbank/indication
  • For prophylactic treatment of kidney transplant rejection (en)
sameAs
Title
  • Basiliximab (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Basiliximab binds with high-affinity to the alpha-subunit (CD25) of the high-affinity IL-2 receptor. This inhibits IL-2 binding, which inhibits T-cell activation and prevents the body from mounting an immune response against the foreign kidney. (en)
http://linked.open...drugbank/packager
http://linked.open...y/drugbank/patent
http://linked.open.../drugbank/synonym
  • Ig gamma-1 chain C region (en)
  • chimeric mouse-human antiCD25 (en)
http://linked.open...umeOfDistribution
  • * 7.8 ± 5.1 L [Pediatric] * 4.8 ± 2.1 L [Adult] (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...y/mesh/hasConcept
foaf:page
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...l/drug/hasATCCode
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 152923-56-3 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...rugbank/clearance
  • * 41 +/- 19 mL/h [Adult patients undergoing first kidney transplantation] * 17 +/- 6 mL/h [pediatric patients undergoing renal transplantation] * 31 +/- 19 mL/h [adolescent patients undergoing renal transplantation] (en)
http://linked.open...gbank/containedIn
http://linked.open...nk/Hydrophobicity
http://linked.open...Isoelectric-Point
http://linked.open...ank/Melting-Point
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