About: Rituximab

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Rituxan is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light- and heavy-chain variable region sequences and human constant region sequences. Rituximab is composed of two heavy chains of 451 amino acids and two light chains of 213 amino acids (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4370-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4371-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# McLaughlin P, Grillo-Lopez AJ, Link BK, Levy R, Czuczman MS, Williams ME, Heyman MR, Bence-Bruckler I, White CA, Cabanillas F, Jain V, Ho AD, Lister J, Wey K, Shen D, Dallaire BK: Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J Clin Oncol. 1998 Aug;16(8):2825-33. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9704735 # Edwards JC, Szczepanski L, Szechinski J, Filipowicz-Sosnowska A, Emery P, Close DR, Stevens RM, Shaw T: Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med. 2004 Jun 17;350(25):2572-81. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15201414 # Braendstrup P, Bjerrum OW, Nielsen OJ, Jensen BA, Clausen NT, Hansen PB, Andersen I, Schmidt K, Andersen TM, Peterslund NA, Birgens HS, Plesner T, Pedersen BB, Hasselbalch HC: Rituximab chimeric anti-CD20 monoclonal antibody treatment for adult refractory idiopathic thrombocytopenic purpura. Am J Hematol. 2005 Apr;78(4):275-80. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15795920 # Binder M, Otto F, Mertelsmann R, Veelken H, Trepel M: The epitope recognized by rituximab. Blood. 2006 Sep 15;108(6):1975-8. Epub 2006 May 16. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16705086 # Burton C, Kaczmarski R, Jan-Mohamed R: Interstitial pneumonitis related to rituximab therapy. N Engl J Med. 2003 Jun 26;348(26):2690-1; discussion 2690-1. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12826649 # http://www.google.com/patents/EP2231183A2?cl=en # http://planetorbitrap.com/data/uploads/528fce2e395be.pdf (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	0.8 hours (mammalian reticulocytes, in vitro) (en)
http://linked.open...ugbank/indication	For treatment of CD20-positive non-Hodgkins lymphoma, chronic lymphocytic leukemia, and rheumatoid arthritis. (en)
http://linked.open...bank/manufacturer	Roche
sameAs	Rituximab Rituximab
Title	Rituximab (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00073/identifier/drugbank/DB00073 http://linked.opendata.cz/resource/drugbank/drug/DB00073/identifier/genbank/J00228 http://linked.opendata.cz/resource/drugbank/drug/DB00073/identifier/national-drug-code-directory/50242-053-06 http://linked.opendata.cz/resource/drugbank/drug/DB00073/identifier/pharmgkb/PA451261 http://linked.opendata.cz/resource/drugbank/drug/DB00073/identifier/uniprotkb/P01857 http://linked.opendata.cz/resource/drugbank/drug/DB00073/identifier/wikipedia/Rituximab
http://linked.open...mechanismOfAction	The Fab regions of rituximab binds to the CD20 antigen on B lymphocytes, while the Fc domain recruits antibodies and complements to mediate cell lysis. (en)
http://linked.open...drugbank/packager	Advanced Pharmaceutical Services Inc. Amerisource Health Services Corp. APP Pharmaceuticals
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/1336826 http://linked.opendata.cz/resource/drugbank/patent/2149329 http://linked.opendata.cz/resource/drugbank/patent/5736137
http://linked.open.../drugbank/synonym	AntiCD20 (en) Ig gamma-1 chain C region (en)
http://linked.open...umeOfDistribution	* 3.1 L (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/10-00-00
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0244307
foaf:page	http://www.drugs.com/cdi/rituximab.html http://www.rxlist.com/cgi/generic/ritux.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4376-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4375-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Rituximab
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	174722-31-7 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 0.34 L/day [RA patients] (en)
http://linked.open...gbank/containedIn	Fluorouracil 2% Solution 10ml Bottle Fluorouracil 5% Solution 10ml Bottle
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B4373-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B4374-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B4372-363D-11E5-9242-09173F13E4C5

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