About: Interferon beta-1b

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Human interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B432D-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B432E-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	Interferon beta-1b is a drug used for the treatment of relapsing/remitting multiple sclerosis. It has been shown to slow the advance of the disease as well as to decrease the frequency of attacks. (en)
sameAs	Interferon beta-1b Interferon beta-1b
Title	Interferon beta-1b (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00068/identifier/drugbank/DB00068 http://linked.opendata.cz/resource/drugbank/drug/DB00068/identifier/genbank/V00534 http://linked.opendata.cz/resource/drugbank/drug/DB00068/identifier/kegg-compound/C07901 http://linked.opendata.cz/resource/drugbank/drug/DB00068/identifier/kegg-drug/D00746 http://linked.opendata.cz/resource/drugbank/drug/DB00068/identifier/national-drug-code-directory/50419-523-35 http://linked.opendata.cz/resource/drugbank/drug/DB00068/identifier/uniprotkb/P01574 http://linked.opendata.cz/resource/drugbank/drug/DB00068/identifier/pharmgkb/PA450039 http://linked.opendata.cz/resource/drugbank/drug/DB00068/identifier/wikipedia/Interferon_beta-1b
http://linked.open...mechanismOfAction	Interferon beta binds to type I interferon receptors (IFNAR1 and IFNAR2c) which activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon beta binds more stably to type I interferon receptors than interferon alpha. (en)
http://linked.open...drugbank/packager	Bayer Healthcare Berlex Labs Astellas Pharma Inc. Ben Venue Laboratories Inc. Bristol-Myers Squibb Co.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/1339707 http://linked.opendata.cz/resource/drugbank/patent/1340861
http://linked.open.../drugbank/synonym	Fibroblast interferon (en) IFN-beta (en) Interferon beta precursor (en)
http://linked.open...umeOfDistribution	* 0.25 to 2,88 L/kg (en)
http://linked.open...ynthesisReference	Heinz-Jurgen Friesen, Sidney Pestka, "Preparation of homogeneous human fibroblast interferon." U.S. Patent US4289689, issued December, 1968. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0129586
foaf:page	http://www.drugs.com/cdi/interferon-beta-1b-solution.html http://www.rxlist.com/cgi/generic/interferon_beta.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4332-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4331-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Interferon beta-1b
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	145155-23-3 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 9.4 – 28.9 mL/min•kg-1 [patients with diseases other than MS receiving single intravenous doses up to 2.0 mg] (en)
http://linked.open...gbank/containedIn	Extavia 0.3 mg kit Betaseron 0.3 mg kit Betaseron 14 0.3 mg Solution 1 Box Contains Fourteen .3 mg Vials.
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B432F-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B4330-363D-11E5-9242-09173F13E4C5

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