About: Vasopressin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Antidiuretic hormone, also known as vasopressin, is a nine amino acid peptide secreted from the posterior pituitary. Antidiuretic hormone binds to receptors in the distal or collecting tubules of the kidney and promotes reabsorbtion of water back into the circulation (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4320-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Bielsky IF, Hu SB, Szegda KL, Westphal H, Young LJ: Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice. Neuropsychopharmacology. 2004 Mar;29(3):483-93. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14647484 # Wersinger SR, Caldwell HK, Martinez L, Gold P, Hu SB, Young WS 3rd: Vasopressin 1a receptor knockout mice have a subtle olfactory deficit but normal aggression. Genes Brain Behav. 2007 Aug;6(6):540-51. Epub 2006 Nov 3. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17083331 # Lolait SJ, Stewart LQ, Jessop DS, Young WS 3rd, O'Carroll AM: The hypothalamic-pituitary-adrenal axis response to stress in mice lacking functional vasopressin V1b receptors. Endocrinology. 2007 Feb;148(2):849-56. Epub 2006 Nov 22. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17122081 # Wersinger SR, Kelliher KR, Zufall F, Lolait SJ, O'Carroll AM, Young WS 3rd: Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task. Horm Behav. 2004 Dec;46(5):638-45. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15555506 # Kanwar S, Woodman RC, Poon MC, Murohara T, Lefer AM, Davenpeck KL, Kubes P: Desmopressin induces endothelial P-selectin expression and leukocyte rolling in postcapillary venules. Blood. 1995 Oct 1;86(7):2760-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7545469 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	10-20 minutes (en)
http://linked.open...ugbank/indication	For the treatment of enuresis, polyuria, diabetes insipidus, polydipsia and oesophageal varices with bleeding (en)
http://linked.open...bank/manufacturer	Parke davis div warner lambert co
sameAs	Vasopressin Vasopressin
Title	Vasopressin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00067/identifier/drugbank/DB00067 http://linked.opendata.cz/resource/drugbank/drug/DB00067/identifier/kegg-compound/C00840 http://linked.opendata.cz/resource/drugbank/drug/DB00067/identifier/kegg-drug/D00101 http://linked.opendata.cz/resource/drugbank/drug/DB00067/identifier/pharmgkb/PA451858 http://linked.opendata.cz/resource/drugbank/drug/DB00067/identifier/wikipedia/Vasopressin
http://linked.open...mechanismOfAction	Vasopressin acts on three different receptors, vasopressin receptor V1a (which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII), vasopressin receptor V1b (which mediates corticotrophin secretion from the pituitary) and vasopressin receptor V2 which controls free water reabsorption in the renal medullar. The binding of vasopressin to the V2 receptor activates adenylate cyclase which causes the release of aquaporin 2 channels into the cells lining the renal medullar duct. This allows water to be reabsorbed down an osmotic gradient so the urine is more concentrated. (en)
http://linked.open...drugbank/packager	American Regent APP Pharmaceuticals APPD A-S Medication Solutions LLC Cardinal Health JHP Pharmaceuticals LLC Luitpold Pharmaceuticals Inc. Pharmaceutical Utilization Management Program VA Inc. PD-Rx Pharmaceuticals Inc.
http://linked.open.../drugbank/synonym	Argipressin (en) ADH (en) AVP (en) Antidiuretic hormone (en) Arginine vasopressin (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/68-28-00
http://linked.open...k/foodInteraction	Ethanol (en)
http://linked.open...nk/proteinBinding	1% (en)
http://linked.open...ynthesisReference	Nedumparambil A. Abraham, Hans U. Immer, Kazimir Sestanj, "Process for producing triglycyl-lysine vasopressin and intermediates therefor." U.S. Patent US4093610, issued June, 1963. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0494241
foaf:page	http://www.drugs.com/mtm/vasopressin.html http://www.rxlist.com/cgi/generic3/vasopressin.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4324-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4323-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B4321-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Vasopressin
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	11000-17-2 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Vasopressin 20 unit/ml vial Metoprolol tartrate 50 mg tablet Lopresor 100 mg Tablet
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B4322-363D-11E5-9242-09173F13E4C5

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