About: Follitropin beta

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Follitropin beta is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. Follitropin beta is produced in genetically engineered Chinese hamster cell lines (CHO). The nomenclature “beta” differentiates it from another recombinant human FSH product that was marketed earlier as follitropin alpha. Follitropin is important in the development of follicles produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. Follitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF). Numerous physio-chemical tests and bioassays indicate that follitropin beta and follitropin alpha are indistinguishable. However, a more recent study showed there is may be a slight clinical difference, with the alpha form tending towards a higher pregnancy rate and the beta form tending towards a lower pregnancy rate, but with significantly higher estradiol (E2) levels. Structural analysis shows that the amino acid sequence of follitropin beta is identical to that of natural human follicle stimulating hormone (FSH). Further, the ogliosaccharide side chains are very similar, but not completely identical to that of natural FSH. However, these small differences do not affect the bioactivity compared to natural FSH. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B430B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B430C-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B430D-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Goa KL, Wagstaff AJ: Follitropin alpha in infertility: a review. BioDrugs. 1998 Mar;9(3):235-60. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18020563 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	Circulation half life of 3-4 hours, elimination half life of 35-40 hours (en)
http://linked.open...ugbank/indication	For treatment of female infertility (en)
http://linked.open...bank/manufacturer	Duramed Econolab Inc.
sameAs	Follitropin beta Follitropin beta
Title	Follitropin beta (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00066/identifier/drugbank/DB00066 http://linked.opendata.cz/resource/drugbank/drug/DB00066/identifier/genbank/M16647 http://linked.opendata.cz/resource/drugbank/drug/DB00066/identifier/national-drug-code-directory/0052-0306-31 http://linked.opendata.cz/resource/drugbank/drug/DB00066/identifier/uniprotkb/P01225 http://linked.opendata.cz/resource/drugbank/drug/DB00066/identifier/pharmgkb/PA449693 http://linked.opendata.cz/resource/drugbank/drug/DB00066/identifier/wikipedia/Follicle-stimulating_hormone
http://linked.open...mechanismOfAction	Follitropin alpha is a recombinant form of endogenous follicle stimulating hormone (FSH). FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells. (en)
http://linked.open...drugbank/packager	Corvit Pharmaceuticals DHHS Program Support Center Supply Service Center Direct Dispensing Inc.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/2037884 http://linked.opendata.cz/resource/drugbank/patent/5270057 http://linked.opendata.cz/resource/drugbank/patent/7741268
http://linked.open...outeOfElimination	Via liver and kidneys (en)
http://linked.open.../drugbank/synonym	Follitropin beta (en) FSH-B (en) FSH-beta (en) Follicle-stimulating hormone beta subunit (en) Follitropin beta chain precursor (en) FSH-b (en) Follicle stimulating hormone beta (en) Follitrophin beta (en)
http://linked.open...umeOfDistribution	* 8 L [female subjects following intravenous administration of a 300 IU dose] (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0573063
foaf:page	http://www.drugs.com/cdi/follitropin-alfa-powder.html http://www.rxlist.com/cgi/generic3/follitrop.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4312-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4311-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Follitropin beta
http://linked.open...ugbank/absorption	74% (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	9002-68-0 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 0.01 1h-1kg-1 [European women with a single intramuscular dose of 300 IU] 0.01 1*h-1kg-1 [Japanese women with a single intramuscular dose of 300 IU] (en)
http://linked.open...gbank/containedIn	Ortho-Cyclen (28) 28 0.25-35 mg-mcg tablet Disp Pack Gonal-f rff 75 unit vial Adalat CC 30 mg 24 Hour tablet Follistim aq 300 unit cartridge Afeditab cr 60 mg tablet Apo-Metoprolol 25 mg Tablet Azilect 0.5 mg tablet Apo-Metoprolol (Type L) 50 mg Tablet Apo-Metoprolol 50 mg Tablet Follistim AQ 900unt/1.08ml Solution 1 Cartridge = 1.17ml Gonal-f rff 900 unit pen
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B430F-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B4310-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B430E-363D-11E5-9242-09173F13E4C5

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