About: Pegaspargase

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Pegylated L-asparagine amidohydrolase from E. coli. Pegylation substantially (by a factor of 4) extends the protein half life. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4290-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Graham ML: Pegaspargase: a review of clinical studies. Adv Drug Deliv Rev. 2003 Sep 26;55(10):1293-302. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14499708 #Lexicomp Online (2014). Pegaspargase. Available at:http://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/7445#f_adverse-reactions [Accessed 12 Nov. 2014]. #American Society of Health System Pharmacists, Inc., DynaMed [Internet]. Ipswich (MA): EBSCO Information Services. 1995. Pegaspargase; [updated 2013 Jan 18; cited 2014 Nov 12]. Available from http://search.ebscohost.com/login.aspx?direct=true&site=DynaMed&id=233015. (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	IM: ~6 days; half-life decreased to ~3 days (range: 1.4 to 5 days) in patients with previous hypersensitivity to native L-asparaginase; IV: Adults (asparaginase naive): 7 days (en)
http://linked.open...ugbank/indication	For treatment of acute lymphoblastic leukemia (en)
sameAs	Pegaspargase Pegaspargase
Title	Pegaspargase (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00059/identifier/drugbank/DB00059 http://linked.opendata.cz/resource/drugbank/drug/DB00059/identifier/genbank/U00096 http://linked.opendata.cz/resource/drugbank/drug/DB00059/identifier/national-drug-code-directory/57665-002-02 http://linked.opendata.cz/resource/drugbank/drug/DB00059/identifier/uniprotkb/P37595 http://linked.opendata.cz/resource/drugbank/drug/DB00059/identifier/pharmgkb/PA164760860 http://linked.opendata.cz/resource/drugbank/drug/DB00059/identifier/wikipedia/Pegaspargase
http://linked.open...mechanismOfAction	Pegaspargase, more effective than asparaginase, converts asparagine to aspartic acid and ammonia. It facilitates production of oxaloacetate which is needed for general cellular metabolism. Some malignant cells lose the ability to produce asparagine and so the loss of exogenous sources of asparagine leads to cell death. (en)
http://linked.open...drugbank/packager	Ben Venue Laboratories Inc. Actavis totowa llc
http://linked.open.../drugbank/synonym	L-asparagine amidohydrolase (en) Putative L-asparaginase precursor (en)
http://linked.open...drugbank/toxicity	Adverse effects that occur more than 10% of the time include hepatotoxicity as it is known to increase serum transaminases (ALT, AST). Also known to induce hypersensitivity reactions including anaphylaxis, erythema and bronchospasm. (en)
http://linked.open...umeOfDistribution	IV: Adults (asparaginase naive): 2.4 L/m2 Distributes into CSF (reportedly reducing CSF asparagine concentrations to a similar extent as asparaginase (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0125979
foaf:page	http://www.drugs.com/cdi/pegaspargase.html http://www.rxlist.com/cgi/generic2/pegaspargase.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4294-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4293-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Pegaspargase
http://linked.open...ugbank/absorption	Onset of Asparagine depletion by IM is within 4 days Time to peak: IM: 3 to 4 days (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	130167-69-0 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Oncaspar 750 unit/ml vial
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B4291-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B4292-363D-11E5-9242-09173F13E4C5

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