About: Alpha-1-proteinase inhibitor

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About: Alpha-1-proteinase inhibitor Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4287-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Karnaukhova E, Ophir Y, Golding B: Recombinant human alpha-1 proteinase inhibitor: towards therapeutic use. Amino Acids. 2006 Jun;30(4):317-32. Epub 2006 May 26. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16773239 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For treatment of panacinar emphysema (en)
sameAs	Alpha-1-proteinase inhibitor Alpha-1-proteinase inhibitor
Title	Alpha-1-proteinase inhibitor (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00058/identifier/drugbank/DB00058 http://linked.opendata.cz/resource/drugbank/drug/DB00058/identifier/genbank/K01396 http://linked.opendata.cz/resource/drugbank/drug/DB00058/identifier/national-drug-code-directory/0944-2802-01 http://linked.opendata.cz/resource/drugbank/drug/DB00058/identifier/uniprotkb/P01009 http://linked.opendata.cz/resource/drugbank/drug/DB00058/identifier/pharmgkb/PA10308 http://linked.opendata.cz/resource/drugbank/drug/DB00058/identifier/wikipedia/Alpha_1-antitrypsin
http://linked.open...mechanismOfAction	Alpha-1 proteinase inhibitor is a serine protease inhibitor (Serpin). Its primary mechanism is inhibiting the action of the serine protease called elastase (also plasmin and thrombin) in the lungs. The reactive center loop (RCL) of alpha-1 proteinase inhibitor extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable. (en)
http://linked.open...drugbank/packager	Baxter International Inc. CSL Behring LLC Monte Sano Pharmaceuticals Inc.
http://linked.open.../drugbank/synonym	Alpha 1-antitrypsin (en) Alpha-1 protease inhibitor (en) Alpha-1-antiproteinase (en) Alpha-1-antitrypsin precursor (en)
http://linked.open...umeOfDistribution	* 5632 ± 2006 mL [ARALAST NP] * 5618 ± 1618 mL [Aralast] (en)
http://linked.open...ynthesisReference	Michael H. Coan, William J. Brockway, "Method of preparing alpha-1-proteinase inhibitor." U.S. Patent US4379087, issued December, 1968. (en)
foaf:page	http://www.rxlist.com/cgi/generic3/zemaira.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B428C-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B428B-363D-11E5-9242-09173F13E4C5
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	9041-92-3 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 940 +/- 275 mL/day [Patients with congenital α1-PI deficiency with single IV infusion of 60 mg/kg] (en)
http://linked.open...gbank/containedIn	Hyzaar 100-25 mg tablet Prolastin 500 mg vial Losartan Potassium 90 50 mg tablet Bottle Aralast 500 mg vial Zemaira 1000 mg vial Ahist 12 mg tablet Aralast np 1000 mg vial Allergy 4 mg tablet
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B4289-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B428A-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B4288-363D-11E5-9242-09173F13E4C5

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