About: Drotrecogin alfa

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated that it was not effective in improving outcomes in patients with sepsis. (en)
http://linked.open...gy/drugbank/group	approved (en) withdrawn (en) investigational (en)
http://linked.open...drugbank/halfLife	5.5 hours (mammalian reticulocytes, in vitro). (en)
http://linked.open...ugbank/indication	For reduction of mortality in patients with severe sepsis. (en)
sameAs	Drotrecogin alfa Drotrecogin alfa
Title	Drotrecogin alfa (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00055/identifier/drugbank/DB00055 http://linked.opendata.cz/resource/drugbank/drug/DB00055/identifier/genbank/M11228 http://linked.opendata.cz/resource/drugbank/drug/DB00055/identifier/national-drug-code-directory/0002-7559-01 http://linked.opendata.cz/resource/drugbank/drug/DB00055/identifier/uniprotkb/P04070 http://linked.opendata.cz/resource/drugbank/drug/DB00055/identifier/pharmgkb/PA131548935 http://linked.opendata.cz/resource/drugbank/drug/DB00055/identifier/wikipedia/Drotrecogin_alfa
http://linked.open...mechanismOfAction	Activated protein C combines with protein S on platelet surfaces and then degrades factor Va and factor VIIIa, thereby reducing blood coagulability. (en)
http://linked.open...drugbank/packager	App pharmaceuticals llc Bristol myers squibb
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/2036894 http://linked.opendata.cz/resource/drugbank/patent/2139468
http://linked.open.../drugbank/synonym	Anticoagulant protein C (en) Autoprothrombin IIA (en) Blood coagulation factor XIV (en) Vitamin K-dependent protein C precursor (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/20-12-20
foaf:page	http://www.drugs.com/cdi/drotrecogin-alfa.html http://www.rxlist.com/cgi/generic/drotrecogin.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4270-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B426F-363D-11E5-9242-09173F13E4C5
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	60202-16-6 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 40 L/hr [severe sepsis adults] * 30 +/- 8 L/hr [patients without sepsis undergoing hemodialysis] * 28 +/- 9 L/hr [heathy] (en)
http://linked.open...gbank/containedIn	Omnipaque 180 mg/ml vial Omnipaque 240 mg/ml vial
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B426D-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B426E-363D-11E5-9242-09173F13E4C5

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