| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - Recombinant human growth hormone (somatotropin) 191 residues, MW 22.1 kD, synthesized in E. coli (en)
|
| http://linked.open...y/drugbank/dosage
| |
| http://linked.open...generalReferences
| - # Seltzer V, Tonge SR: Proceedings: Methylamphetamine withdrawal as a model for the depressive state: antagonism of post-amphetamine depression by imipramine. J Pharm Pharmacol. 1975 Dec;27 Suppl?-2:16P. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2688 # Alba-Roth J, Muller OA, Schopohl J, von Werder K: Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. J Clin Endocrinol Metab. 1988 Dec;67(6):1186-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2903866 # Scarth JP: Modulation of the growth hormone-insulin-like growth factor (GH-IGF) axis by pharmaceutical, nutraceutical and environmental xenobiotics: an emerging role for xenobiotic-metabolizing enzymes and the transcription factors regulating their expression. A review. Xenobiotica. 2006 Feb-Mar;36(2-3):119-218. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16702112 # Takahashi Y, Kipnis DM, Daughaday WH: Growth hormone secretion during sleep. J Clin Invest. 1968 Sep;47(9):2079-90. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/5675428 (en)
|
| http://linked.open...gy/drugbank/group
| - approved (en)
- investigational (en)
|
| http://linked.open...ugbank/indication
| - For treatment of dwarfism, acromegaly and prevention of HIV-induced weight loss (en)
|
| http://linked.open...bank/manufacturer
| |
| sameAs
| |
| Title
| - Somatropin recombinant (en)
|
| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - hGH binds to the human growth hormone receptor (GHR). Upon binding, hGH causes dimerization of GHR, activation of the GHR-associated JAK2 tyrosine kinase, and tyrosyl phosphorylation of both JAK2 and GHR. These events recruit and/or activate a variety of signaling molecules, including MAP kinases, insulin receptor substrates, phosphatidylinositol 3' phosphate kinase, diacylglycerol, protein kinase C, intracellular calcium, and Stat transcription factors. These signaling molecules contribute to the GH-induced changes in enzymatic activity, transport function, and gene expression that ultimately culminate in changes in growth and metabolism. (en)
|
| http://linked.open...drugbank/packager
| |
| http://linked.open...y/drugbank/patent
| |
| http://linked.open...outeOfElimination
| - Although calcium excretion in the urine is increased, there is a simultaneous increase in calcium absorption from the intestine. Somatropin stimulates the synthesis of chondroitin sulfate and collagen, and increases the urinary excretion of hydroxyproline. (en)
|
| http://linked.open.../drugbank/synonym
| - Somatropin (en)
- GH (en)
- GH-N (en)
- Growth hormone (en)
- Growth hormone 1 (en)
- Pituitary growth hormone (en)
- Somatotropin precursor (en)
|
| http://linked.open...ynthesisReference
| - Mandayam J. Narasimhan, John A. Anderson, "Process for the large scale production of human growth hormone by serial secondary suspension culture." U.S. Patent US4124448, issued January, 1963. (en)
|
| foaf:page
| |
| http://linked.open...Molecular-Formula
| |
| http://linked.open.../Molecular-Weight
| |
| http://linked.open...l/drug/hasATCCode
| |
| http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
|
| http://linked.open...casRegistryNumber
| |
| http://linked.open...drugbank/category
| |
| http://linked.open...rugbank/clearance
| - * 2.3 +/- 1.8 mL/min/kg [GHD patients (IV 33 ng/kg/min)] (en)
|
| http://linked.open...gbank/containedIn
| |
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