About: Collagenase

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	The enzyme collagenase is derived from fermentation of Clostridium histolyticum (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B41AE-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Norris DB, Trudgill PW: Multiple forms of cyclohexanone oxygenase from Nocardia globerula CL1. Eur J Biochem. 1976 Mar 16;63(1):193-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/4312 # Pajot P: Fluroescence of proteins in 6-M guanidine hydrochloride. A method for the quantitative determination of tryptophan. Eur J Biochem. 1976 Mar 16;63(1):263-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/4317 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...ugbank/indication	Used to promote debridement of necrotic tissue in the treatment of severe burns and dermal ulcers including decubitus ulcers. (en)
sameAs	Collagenase Collagenase
Title	Collagenase (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00048/identifier/drugbank/DB00048 http://linked.opendata.cz/resource/drugbank/drug/DB00048/identifier/kegg-compound/C00816 http://linked.opendata.cz/resource/drugbank/drug/DB00048/identifier/pharmgkb/PA449107 http://linked.opendata.cz/resource/drugbank/drug/DB00048/identifier/wikipedia/Collagenase
http://linked.open...mechanismOfAction	Collagenase is a protease that is specific to collagen. The triple helical region of interstitial collagens is highly resistant to most cell proteinases. However, during remodeling of the connective tissue in such processes as wound healing and metastasis, collagen becomes susceptible to cleavage by collagenases. Collagenase cleaves all 3 alpha helical chains of native Types I, II and III collagens at a single locus by hydrolyzing the peptide bond following the Gly residue of the sequence: Gly 775-(Ile or Leu) 776-(Ala or Leu) 777 located approximately three-fourths of the chain length from each N-terminus (en)
http://linked.open...drugbank/packager	Abbott Laboratories Ltd. Advance Biofactures Corp. Auxilium Pharmaceuticals B&B Pharmaceuticals Advanced Pharmaceutical Services Inc. Amerisource Health Services Corp. Anip Acquisition Co.
http://linked.open.../drugbank/synonym	AA4500 (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/84-92-00
http://linked.open...ynthesisReference	Hun-Chi Lin, Shau-Ping Lei, "Molecular cloning of the genes responsible for collagenase production from Clostridium histolyticum." U.S. Patent US5177017, issued December, 1972. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0026363
foaf:page	http://www.drugs.com/cdi/collagenase-ointment.html http://www.rxlist.com/cgi/generic3/collagenase.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B41B2-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B41B1-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Collagenase
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	9001-12-1 (en)
http://linked.open...gbank/containedIn	Cefuroxime axetil 250 mg tablet Ceftin 500 mg Tablet Cefzil 250 mg tablet Duricef 1 gm tablet
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B41AF-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B41B0-363D-11E5-9242-09173F13E4C5

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