About: Botulinum Toxin Type B

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Neurotoxin produced by fermentation of clostridium botulinum type B. The protein exists in noncovalent association with hemagglutinin and nonhemagglutinin proteins as a neurotoxin complex. The neurotoxin complex is recovered from the fermentation process and purified through a series of precipitation and chromatography steps. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4158-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4159-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B415A-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Montecucco C, Molgo J: Botulinal neurotoxins: revival of an old killer. Curr Opin Pharmacol. 2005 Jun;5(3):274-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15907915 # Brin MF, Lew MF, Adler CH, Comella CL, Factor SA, Jankovic J, O'Brien C, Murray JJ, Wallace JD, Willmer-Hulme A, Koller M: Safety and efficacy of NeuroBloc (botulinum toxin type B) in type A-resistant cervical dystonia. Neurology. 1999 Oct 22;53(7):1431-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10534247 # Shukla HD, Sharma SK: Clostridium botulinum: a bug with beauty and weapon. Crit Rev Microbiol. 2005;31(1):11-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15839401 # Eisenach JH, Atkinson JL, Fealey RD: Hyperhidrosis: evolving therapies for a well-established phenomenon. Mayo Clin Proc. 2005 May;80(5):657-66. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15887434 # Schurch B, Corcos J: Botulinum toxin injections for paediatric incontinence. Curr Opin Urol. 2005 Jul;15(4):264-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15928517 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For the treatment of patients with cervical dystonia to reduce the severity of abnormal head position and neck pain associated with cervical dystonia. (en)
sameAs	Botulinum Toxin Type B Botulinum Toxin Type B
Title	Botulinum Toxin Type B (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00042/identifier/drugbank/DB00042 http://linked.opendata.cz/resource/drugbank/drug/DB00042/identifier/genbank/M81186 http://linked.opendata.cz/resource/drugbank/drug/DB00042/identifier/kegg-drug/D02735 http://linked.opendata.cz/resource/drugbank/drug/DB00042/identifier/uniprotkb/P10844 http://linked.opendata.cz/resource/drugbank/drug/DB00042/identifier/pharmgkb/PA164747061 http://linked.opendata.cz/resource/drugbank/drug/DB00042/identifier/wikipedia/Botulinum_toxin
http://linked.open...mechanismOfAction	Botulinum Toxin Type B binds to and cleaves the synaptic Vesicle Associated Membrane Protein (VAMP, also known as synaptobrevin) which is a component of the protein complex responsible for docking and fusion of the synaptic vesicle to the presynaptic membrane, a necessary step to neurotransmitter release. (en)
http://linked.open...drugbank/packager	Solstice Neurosciences
http://linked.open.../drugbank/synonym	BTX-B (en) Botulinum neurotoxin type B precursor (en)
http://linked.open...drugbank/toxicity	One unit of Botulinum Toxin Type B corresponds to the calculated median lethal intraperitoneal dose (LD50) in mice. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0253447
foaf:page	http://www.drugs.com/cdi/botulinum-toxin-type-b.html http://www.rxlist.com/cgi/generic/botulinumtoxin.htm
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B415B-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Though pharmacokinetic or ADME studies were not performed, Botulinum Toxin Type B is not expected to be present in the peripheral blood at measurable levels following IM injection at the recommended doses. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	93384-44-2 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Floxin 200 mg tablet Cetraxal 0.2% ear solution

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