About: Glucagon recombinant

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	29 residue peptide hormone. Glucagon is synthesized in a special non- pathogenic laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for glucagons (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4141-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4142-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# White CM: A review of potential cardiovascular uses of intravenous glucagon administration. J Clin Pharmacol. 1999 May;39(5):442-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10234590 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For treatment of severe hypoglycemia, also used in gastrointestinal imaging (en)
http://linked.open...bank/manufacturer	Aurobindo pharma ltd Apotex inc
sameAs	Glucagon recombinant Glucagon recombinant
Title	Glucagon recombinant (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00040/identifier/drugbank/DB00040 http://linked.opendata.cz/resource/drugbank/drug/DB00040/identifier/genbank/AF529185 http://linked.opendata.cz/resource/drugbank/drug/DB00040/identifier/kegg-compound/C01501 http://linked.opendata.cz/resource/drugbank/drug/DB00040/identifier/kegg-drug/D00116 http://linked.opendata.cz/resource/drugbank/drug/DB00040/identifier/national-drug-code-directory/0002-8031-01 http://linked.opendata.cz/resource/drugbank/drug/DB00040/identifier/uniprotkb/Q8MJ25 http://linked.opendata.cz/resource/drugbank/drug/DB00040/identifier/pharmgkb/PA164779052 http://linked.opendata.cz/resource/drugbank/drug/DB00040/identifier/wikipedia/Glucagon_recombinant
http://linked.open...mechanismOfAction	Glucagon binds the glucagon receptor, a G protein-coupled receptor located in the plasma membrane, which then initiates a dual signaling pathway using both adenylate cyclase activation and increased intracellular calcium. Adenylate cyclase manufactures cAMP (cyclic AMP), which activates protein kinase A (cAMP-dependent protein kinase). This enzyme, in turn, activates phosphorylase kinase, which, in turn, phosphorylates glycogen phosphorylase, converting into the active form called phosphorylase A. Phosphorylase A is the enzyme responsible for the release of glucose-1-phosphate from glycogen polymers. This yields glucose molecules to be released into the blood. Glucagon receptors are found in the liver, kidney, brain and pancreatic islet cells. The glucagon mediated signals lead to an increase in insulin excretion (en)
http://linked.open...drugbank/packager	Bedford Labs Eli Lilly & Co. Sandoz Depomed inc
http://linked.open.../drugbank/synonym	Glucagon (en) His-ser-glu(NH2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr (en) Glucagone (en) Glucagonum (en) HSQGTFTSDYSKYLDSRRAQDFVQWLMNT (en) His-ser-gln-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-gln-asp-phe-val-gln-trp-leu-met-asn-thr (en)
http://linked.open...umeOfDistribution	* 0.25 L/kg (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/68-22-12
foaf:page	http://www.drugs.com/cdi/glucagon.html http://www.rxlist.com/cgi/generic2/gluca.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4146-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4145-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Glucagon
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	9007-92-5 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 13.5 mL/min/kg [Adults with IV 1 mg] (en)
http://linked.open...gbank/containedIn	Glucagen 1 mg vial Glucagon 1 mg/vial Glucagon 1 mg emergency kit Glucagen 1 mg hypokit GlucaGen HypoKit 1 mg Solution Box Glucagon Emergency 1 mg Kit Box Copegus 200 mg tablet
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B4143-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B4144-363D-11E5-9242-09173F13E4C5

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