About: Oprelvekin

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About: Oprelvekin Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Oprelvekin, the active ingredient in Neumega® is recombinant Interleukin eleven, which is produced in Escherichia coli (E. coli) by recombinant DNA technology. The protein has a molecular mass of approximately 19,000 daltons, and is non-glycosylated. The polypeptide is 177 amino acids in length (the natural IL-11 has 178). This alteration has not resulted in measurable differences in bioactivity either in vitro or in vivo. The primary hematopoietic activity of Neumega® is stimulation of megakaryocytopoiesis and thrombopoiesis. In mice and nonhuman primate studies Neumega® has shown potent thrombopoietic activity in compromised hematopoiesis, including moderately to severely myelosuppressed animals. In these studies, Neumega® improved platelet nadirs and accelerated platelet recoveries compared to controls. In animal studies Oprelvekin also has non-hematopoetic activities. This includes the regulation of intestinal epithelium growth (enhanced healing of gastrointestinal lesions), the inhibition of adipogenesis, the induction of acute phase protein synthesis (e.g., fibrinogen), and inhibition of macrophageal released pro-inflammatory cytokines. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4125-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	6.9 +/- 1.7 hrs (en)
http://linked.open...ugbank/indication	Increases reduced platelet levels due to chemotherapy (en)
sameAs	Oprelvekin Oprelvekin
Title	Oprelvekin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00038/identifier/drugbank/DB00038 http://linked.opendata.cz/resource/drugbank/drug/DB00038/identifier/genbank/M57765 http://linked.opendata.cz/resource/drugbank/drug/DB00038/identifier/national-drug-code-directory/58394-004-01 http://linked.opendata.cz/resource/drugbank/drug/DB00038/identifier/uniprotkb/P20809 http://linked.opendata.cz/resource/drugbank/drug/DB00038/identifier/pharmgkb/PA164747991 http://linked.opendata.cz/resource/drugbank/drug/DB00038/identifier/wikipedia/Oprelvekin
http://linked.open...mechanismOfAction	Oprelvekin binds to the interleukin 11 receptor which leads to a cascade of signal transduction events. IL-11 is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. (en)
http://linked.open...drugbank/packager	Bayer healthcare pharmaceuticals inc Bayer pharmaceuticals corp
http://linked.open...outeOfElimination	The kidney is the primary route of elimination. The amount of intact Neumega in urine was low, indicating that the molecule was metabolized before excretion. (en)
http://linked.open.../drugbank/synonym	AGIF (en) Adipogenesis inhibitory factor (en) IL-11 (en) Interleukin-11 precursor (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0274767
foaf:page	http://www.drugs.com/cdi/oprelvekin.html http://www.rxlist.com/cgi/generic3/oprelvek.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4129-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4128-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Oprelvekin
http://linked.open...ugbank/absorption	Absolute bioavailability is over 80%. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	145941-26-0 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Chlorpropamide 250 mg tablet
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B4126-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B4127-363D-11E5-9242-09173F13E4C5

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