| Attributes | Values |
|---|
| rdf:type
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| http://linked.open...gbank/description
| - Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence displayed is a cDNA sequence which codes for human interferon gamma, as described by Gray et. al. and not specifically interferon gamma 1b. (en)
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| http://linked.open...y/drugbank/dosage
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| http://linked.open...generalReferences
| - # Kantoch M, Dobrowolska H, Jarzabek Z, Jankowski M, Sadowski W, Janicki P: [Distribution and characteristics of Poliovirus strains circulating in Poland in 1968-1972. Genetic variation of strains isolated in various secretion periods and clones isolated from vaccines] Med Dosw Mikrobiol. 1975;27(4):353-63. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/55526 # Ormas P, Pompa G, Beretta C, Faustini R: [The effects of some polypeptides on the systemic blood pressure of sheep (author's transl)] Folia Vet Lat. 1975 Jan-Mar;5(1):45-54. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/3458 # Selitrennikoff CP, Sonneborn DR: Alkaline phosphatase of Blastocladiella emersonii: partial purification and characterization. J Bacteriol. 1977 Apr;130(1):249-56. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15978 # Gray PW, Goeddel DV: Structure of the human immune interferon gene. Nature. 1982 Aug 26;298(5877):859-63. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6180322 # Ealick SE, Cook WJ, Vijay-Kumar S, Carson M, Nagabhushan TL, Trotta PP, Bugg CE: Three-dimensional structure of recombinant human interferon-gamma. Science. 1991 May 3;252(5006):698-702. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1902591 # Ikeda H, Old LJ, Schreiber RD: The roles of IFN gamma in protection against tumor development and cancer immunoediting. Cytokine Growth Factor Rev. 2002 Apr;13(2):95-109. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11900986 # Chesler DA, Reiss CS: The role of IFN-gamma in immune responses to viral infections of the central nervous system. Cytokine Growth Factor Rev. 2002 Dec;13(6):441-54. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12401479 # Dessein A, Kouriba B, Eboumbou C, Dessein H, Argiro L, Marquet S, Elwali NE, Rodrigues V, Li Y, Doumbo O, Chevillard C: Interleukin-13 in the skin and interferon-gamma in the liver are key players in immune protection in human schistosomiasis. Immunol Rev. 2004 Oct;201:180-90. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15361241 # Joseph AM, Kumar M, Mitra D: Nef: "necessary and enforcing factor" in HIV infection. Curr HIV Res. 2005 Jan;3(1):87-94. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15638726 # Copeland KF: Modulation of HIV-1 transcription by cytokines and chemokines. Mini Rev Med Chem. 2005 Dec;5(12):1093-101. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16375755 # Schroder K, Hertzog PJ, Ravasi T, Hume DA: Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol. 2004 Feb;75(2):163-89. Epub 2003 Oct 2. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14525967 (en)
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| http://linked.open...gy/drugbank/group
| - approved (en)
- investigational (en)
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| http://linked.open...ugbank/indication
| - Interferon gamma-1b is used for the treatment of Chronic granulomatous disease and Osteopetrosis. (en)
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| sameAs
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| Title
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| adms:identifier
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| http://linked.open...mechanismOfAction
| - Binds directly to the type II interferon gamma receptor IFNGR1, leading to a complex of IFNGR1 and IFNGR2. This activates JAK1 and JAK2 kinases which form a STAT1 docking site. This leads to STAT1 phosphorylation, nuclear translocation and initiation of gene transcription of multiple immune-related genes. (en)
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| http://linked.open...drugbank/packager
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| http://linked.open...y/drugbank/patent
| |
| http://linked.open.../drugbank/synonym
| - IFN-gamma (en)
- Immune interferon (en)
- Interferon gamma precursor (en)
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| http://linked.open...ynthesisReference
| - Irwin A. Braude, "Production of human IFN-gamma (immune) interferon." U.S. Patent US4376821, issued December, 1975. (en)
|
| http://linked.open...y/mesh/hasConcept
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| foaf:page
| |
| http://linked.open...Molecular-Formula
| |
| http://linked.open.../Molecular-Weight
| |
| http://linked.open...casRegistryNumber
| |
| http://linked.open...drugbank/category
| |
| http://linked.open...gbank/containedIn
| |
| http://linked.open...nk/Hydrophobicity
| |
| http://linked.open...Isoelectric-Point
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| http://linked.open...ank/Melting-Point
| |
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