About: Gramicidin D

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Gramcidin D is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making up 80%, 6%, and 14% respectively all of which are obtained from the soil bacterial species Bacillus brevis and called collectively gramicidin D. Gramcidins are 15 residue peptides with alternating D and L amino acids. The peptides assemble inside of the hydrophobic interior of the cellular lipid bilayer to form a β-helix. The helix itself is not long enough to span the membrane but it dimerizes to form the elongated channel needed to span the whole membrane. Gramicidin D is used primarily as a topical antibiotic and is one of the three constituents of consumer antibiotic polysporin ophthalmic solution. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4046-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Ketchem RR, Lee KC, Huo S, Cross TA: Macromolecular structural elucidation with solid-state NMR-derived orientational constraints. J Biomol NMR. 1996 Jul;8(1):1-14. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8810522 # Townsley LE, Tucker WA, Sham S, Hinton JF: Structures of gramicidins A, B, and C incorporated into sodium dodecyl sulfate micelles. Biochemistry. 2001 Oct 2;40(39):11676-86. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11570868 # Burkhart BM, Gassman RM, Langs DA, Pangborn WA, Duax WL, Pletnev V: Gramicidin D conformation, dynamics and membrane ion transport. Biopolymers. 1999;51(2):129-44. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10397797 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For treatment of skin lesions, surface wounds and eye infections (en)
sameAs	Gramicidin D Gramicidin D
Title	Gramicidin D (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00027/identifier/drugbank/DB00027 http://linked.opendata.cz/resource/drugbank/drug/DB00027/identifier/kegg-drug/D04369 http://linked.opendata.cz/resource/drugbank/drug/DB00027/identifier/pharmgkb/PA449808 http://linked.opendata.cz/resource/drugbank/drug/DB00027/identifier/wikipedia/Gramicidin_D
http://linked.open...mechanismOfAction	Gramicidin D binds to and inserts itself into bacterial membranes (with a strong preference to gram-positive cell membranes). This results in membrane disruption and permeabilization (it acts as a channel). This leads to (i) loss of intracellular solutes (e.g., K+ and amino acids); (ii) dissipation of the transmembrane potential; (iii) inhibition of respiration; (iv) a reduction in ATP pools; and (v) inhibition of DNA, RNA, and protein synthesis, which leads to cell death. (en)
http://linked.open...drugbank/packager	Johnson & Johnson Healthcare Monarch Pharmacy Professional Co.
http://linked.open.../drugbank/synonym	Gramicidin (en) Gramicidin A (en) Gramicidin B (en) Gramicidin C (en) Gramicidine (en)
http://linked.open.../drugbank/mixture	Neocidin
http://linked.open...ynthesisReference	U.S.Patent 2,534,541. (en)
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4049-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4048-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Gramicidin
http://linked.open.../affectedOrganism	Neisseria meningitidis (en) Streptococcus pneumoniae (en) Escherichia coli (en) Pseudomonas aeruginosa (en) Enterobacter (en) Haemophilus influenzae (en) Klebsiella (en) Neisseria gonorrhoeae (en) Staphylococcus aureus (en) Streptococcus agalactiae (en)
http://linked.open...casRegistryNumber	1405-97-6 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Apo-Cilazapril 2.5 mg Tablet Co Cilazapril 2.5 mg Tablet Mylan-Cilazapril 2.5 mg Tablet
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B4047-363D-11E5-9242-09173F13E4C5

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