About: Thyrotropin Alfa

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Thyrotropin Alfa Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of thyroid cancer. It is a heterodimeric glycoprotein comprised of two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites and a beta subunit of 112 residues containing one N-linked glycosylation site. The alpha subunit is nearly identical to that of human chorionic gonadotropin (hCG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The alpha subunit is thought to be the effector region responsible for stimulation of adenylate cyclase (involved the generation of cAMP). The beta subunit (TSHB) is unique to TSH, and therefore determines its receptor specificity. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B3FF3-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3FF4-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3FF5-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Lexicomp #Product label (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	25 ± 10 hours (en)
http://linked.open...ugbank/indication	For detection of residueal or recurrent thyroid cancer (en)
http://linked.open...bank/manufacturer	Nexgen Pharma Inc. Genzyme corp
sameAs	Thyrotropin Alfa Thyrotropin Alfa
Title	Thyrotropin Alfa (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00024/identifier/drugbank/DB00024 http://linked.opendata.cz/resource/drugbank/drug/DB00024/identifier/genbank/M16647 http://linked.opendata.cz/resource/drugbank/drug/DB00024/identifier/national-drug-code-directory/58468-1849-4 http://linked.opendata.cz/resource/drugbank/drug/DB00024/identifier/uniprotkb/P01225 http://linked.opendata.cz/resource/drugbank/drug/DB00024/identifier/pharmgkb/PA164746560
http://linked.open...mechanismOfAction	Thyrotropin Alfa binds to the thyrotropin receptors found on any residual thyroid cells or tissues. This stimulates radioactive iodine uptake for better radiodiagnostic imaging. (en)
http://linked.open...drugbank/packager	Genzyme Inc. Nephron Pharmaceuticals Corp.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/5840566
http://linked.open...outeOfElimination	kidney and liver (en)
http://linked.open.../drugbank/synonym	Thyrotropin (en) TSH (en) Thyroid stimulating hormone (en) Thyrotrophin-alfa (en) Thyrotrophin-alpha (en) Thyrotropin-a (en) Thyrotropin-alpha (en) Thytrophin (en) rTSH (en)
http://linked.open...drugbank/toxicity	No difference in efficacy and toxicity between adult and geriatric patients. No studies in lactating women, pregnant women and pediatrics. Cautionary administration is advised. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/36-60-00
http://linked.open...ynthesisReference	19366632 (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0534260
foaf:page	http://www.drugs.com/cdi/thyrotropin-alfa.html http://www.rxlist.com/cgi/generic2/thyrotropin.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B3FFA-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B3FF9-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Thyrotropin alfa
http://linked.open...ugbank/absorption	Time to peak: Median: 10 hours (range: 3-24 hours) After a single intramuscular injection of 0.9 mg of thyrotropin alfa: Cmax= 116+38mU/L, Tmax=22+8.5 hours. AUC=5088+1728 mU·hr/L. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	9002-71-5 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Sertraline hcl powder
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B3FF7-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B3FF8-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B3FF6-363D-11E5-9242-09173F13E4C5

Faceted Search & Find service v1.16.116 as of Feb 22 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of Feb 22 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 67 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software