About: Interferon alfa-n1

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Purified, natural (n is for natural) glycosylated human interferon alpha proteins 166 residues (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	1.2 hours (mammalian reticulocytes, in vitro); >20 hours (yeast, in vivo); >10 hours (Escherichia coli, in vivo). (en)
http://linked.open...ugbank/indication	For treatment of venereal or genital warts caused by the Human Papiloma Virus (en)
sameAs	Interferon alfa-n1 Interferon alfa-n1
Title	Interferon alfa-n1 (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00011/identifier/drugbank/DB00011 http://linked.opendata.cz/resource/drugbank/drug/DB00011/identifier/genbank/J00207 http://linked.opendata.cz/resource/drugbank/drug/DB00011/identifier/uniprotkb/P01563 http://linked.opendata.cz/resource/drugbank/drug/DB00011/identifier/pharmgkb/PA164746538
http://linked.open...mechanismOfAction	Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta. (en)
http://linked.open.../drugbank/synonym	Interferon alpha-2 (en) Interferon alpha-A (en) LeIF A (en)
http://linked.open...k/foodInteraction	Avoid alcohol. (en)
http://linked.open...ynthesisReference	Vladimir G. Debabov, Jury D. Tsygankov, Andrei J. Chistoserdov, Evgeny D. Sverdlov, Lara S. Izotova, Sergei V. Kostrov, Viktor E. Sterkin, Vladimir P. Kuznetsov, Sergei V. Belyaev, Galina S. Monastyrskaya, Irina S. Salomatina, Grigory M. Dolganov, Sergei G. Arsenian, Sergei A. Tsarev, Jury I. Kozlov, Alexandr Y. Strongin, Vsevolod I. Ogarkov, Jury A. Ovchinnikov, "Method for producing human leukocyte interferon alpha-2." U.S. Patent US4680260, issued January, 1982. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0025713
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B3F0B-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B3F0A-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Interferon alfa-n1
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	74899-72-2 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B3F08-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B3F09-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B3F07-363D-11E5-9242-09173F13E4C5

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