About: Etanercept

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B3EB8-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3EB9-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3EBA-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3EBB-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# http://www.genome.jp/dbget-bin/www_bget?D00742 #American Society of Health System Pharmacists, Inc., DynaMed [Internet]. Ipswich (MA): EBSCO Information Services. 1995. Etanercept; [updated 2014 Sept 24 cited 2014 Nov 11]. Available from http://web.b.ebscohost.com.login.ezproxy.library.ualberta.ca/dynamed/detail?vid=4&sid=eeea413d-1490-4efa-bf5d-71f40e1986a1%40sessionmgr111&hid=123&bdata=JnNpdGU9ZHluYW1lZC1saXZlJnNjb3BlPXNpdGU%3d#db=dme&AN=232781 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	102 +/- 30 hrs in individuals with rheumatoid arthritis and 68 hours in healthy adults (en)
http://linked.open...ugbank/indication	For treatment of severe active rheumatoid arthritis in adults, severe juvenile idiopathic arthritis, ankylosing spondylitis, and severe plaque psoriasis. (en)
http://linked.open...bank/manufacturer	Amgen Inc. + Wyeth + Takeda
sameAs	Etanercept Etanercept
Title	Etanercept (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00005/identifier/drugbank/DB00005 http://linked.opendata.cz/resource/drugbank/drug/DB00005/identifier/genbank/M32315 http://linked.opendata.cz/resource/drugbank/drug/DB00005/identifier/kegg-compound/C07897 http://linked.opendata.cz/resource/drugbank/drug/DB00005/identifier/kegg-drug/D00742 http://linked.opendata.cz/resource/drugbank/drug/DB00005/identifier/national-drug-code-directory/58406-455-04 http://linked.opendata.cz/resource/drugbank/drug/DB00005/identifier/pharmgkb/PA449515 http://linked.opendata.cz/resource/drugbank/drug/DB00005/identifier/uniprotkb/P20333 http://linked.opendata.cz/resource/drugbank/drug/DB00005/identifier/wikipedia/Etanercept
http://linked.open...mechanismOfAction	There are two distinct receptors for TNF (TNFRs), a 55 kilodalton protein (p55) and a 75 kilodalton protein (p75). The biological activity of TNF is dependent upon binding to either cell surface receptor (p75 or p55). Etanercept is a dimeric soluble form of the p75 TNF receptor that can bind to two TNF molecules, thereby effectively removing them from circulation. (en)
http://linked.open...drugbank/packager	Amgen Inc. Boehringer Ingelheim Ltd. Carlisle Laboratories Inc. Corepharma LLC Darby Dental Supply Co. Inc. Dispensing Solutions
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/2123593 http://linked.opendata.cz/resource/drugbank/patent/2476934 http://linked.opendata.cz/resource/drugbank/patent/36755 http://linked.opendata.cz/resource/drugbank/patent/7276477
http://linked.open.../drugbank/synonym	CD120b (en) TNF-R2 (en) Tumor necrosis factor receptor 2 (en) Tumor necrosis factor receptor type II (en) Tumor necrosis factor receptor superfamily member 1B precursor (en) p75 (en) p80 TNF-alpha receptor (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/92-00-00
http://linked.open...ynthesisReference	Timothy D. Osslund, Christi L. Clogston, Shon Lee Crampton, Randal B. Bass, "Crystals of etanercept and methods of making thereof." U.S. Patent US07276477, issued October 02, 2007. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0276736
foaf:page	http://www.drugs.com/cdi/etanercept.html http://www.rxlist.com/cgi/generic/etanercept.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B3EC0-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B3EBF-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Etanercept
http://linked.open...ugbank/absorption	Bioavailability following sub-Q administration is approximately 60%. Peak plasma concentrations achieved within 69 hours. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	185243-69-0 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 160 +/- 80 mL/hr [RA patients] (en)
http://linked.open...gbank/containedIn	Crestor 10 mg tablet Crestor 5 mg tablet Crestor 20 mg tablet Crestor 20 mg Tablet Crestor 40 mg Tablet
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B3EBD-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B3EBE-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B3EBC-363D-11E5-9242-09173F13E4C5

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