About: Denileukin diftitox

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B3EA7-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Turturro F: Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders. Expert Rev Anticancer Ther. 2007 Jan;7(1):11-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17187516 # Park M, Liu GT, Piltz-Seymour J, Wisda CL, Rook AH, Junkins-Hopkins JM, Nasta SD, Kim EJ: Vision loss following denileukin diftitox treatment: a case report of possible posterior ischemic optic neuropathy. Leuk Lymphoma. 2007 Apr;48(4):808-11. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17454642 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	70-80 min (en)
http://linked.open...ugbank/indication	For treatment of cutaneous T-cell lymphoma (en)
sameAs	Denileukin diftitox Denileukin diftitox
Title	Denileukin diftitox (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00004/identifier/drugbank/DB00004 http://linked.opendata.cz/resource/drugbank/drug/DB00004/identifier/genbank/V01536 http://linked.opendata.cz/resource/drugbank/drug/DB00004/identifier/national-drug-code-directory/62856-603-01 http://linked.opendata.cz/resource/drugbank/drug/DB00004/identifier/uniprotkb/P00587 http://linked.opendata.cz/resource/drugbank/drug/DB00004/identifier/pharmgkb/PA164750594 http://linked.opendata.cz/resource/drugbank/drug/DB00004/identifier/wikipedia/Denileukin_diftitox
http://linked.open...mechanismOfAction	Denileukin diftitox binds to the high-affinity IL-2 receptor complex. The IL-2 receptor (Tac) subunit is expressed on activated but not resting lymphocytes. The diphtheria toxin associated with Ontak then selectively kills the IL-2 bearing cells. (en)
http://linked.open...drugbank/packager	Sandoz Bryant Ranch Prepack Altana inc
http://linked.open.../drugbank/synonym	DT (en) Diphtheria toxin precursor (en) NAD(+--diphthamide ADP- ribosyltransferase) (en)
http://linked.open...umeOfDistribution	* 0.06 to 0.09 L/kg (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0292631
foaf:page	http://www.drugs.com/cdi/denileukin-diftitox.html http://www.rxlist.com/cgi/generic2/denileukin.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B3EAB-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B3EAA-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Denileukin diftitox
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	173146-27-5 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 0.6 - 2.0 mL/min/kg [Lymphoma] (en)
http://linked.open...gbank/containedIn	Cefazolin-ns 2 g/100 ml
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B3EA8-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B3EA9-363D-11E5-9242-09173F13E4C5

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