About: Cetuximab

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About: Cetuximab Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Epidermal growth factor receptor binding FAB. Cetuximab is composed of the Fv (variable; antigen-binding) regions of the 225 murine EGFr monoclonal antibody specific for the N-terminal portion of human EGFr with human IgG1 heavy and kappa light chain constant (framework) regions. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B3E7F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3E80-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	114 hrs (en)
http://linked.open...ugbank/indication	For treatment of EGFR-expressing metastatic colorectal cancer in patients who are refractory to other irinotecan-based chemotherapy regimens. Cetuximab is also indicated for treatment of squamous cell carcinoma of the head and neck in conjucntion with radiation therapy. (en)
sameAs	Cetuximab Cetuximab
Title	Cetuximab (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00002/identifier/drugbank/DB00002 http://linked.opendata.cz/resource/drugbank/drug/DB00002/identifier/genbank/J00228 http://linked.opendata.cz/resource/drugbank/drug/DB00002/identifier/national-drug-code-directory/66733-948-23 http://linked.opendata.cz/resource/drugbank/drug/DB00002/identifier/pharmgkb/PA10040 http://linked.opendata.cz/resource/drugbank/drug/DB00002/identifier/wikipedia/Cetuximab
http://linked.open...mechanismOfAction	Cetuximab binds to the epidermal growth factor receptor (EGFr) on both normal and tumor cells. EGFr is over-expressed in many colorectal cancers. Cetuximab competitively inhibits the binding of epidermal growth factor (EGF) and TGF alpha, thereby reducing their effects on cell growth and metastatic spread. (en)
http://linked.open...drugbank/packager	Cardinal Health Catalent Pharma Solutions ImClone Systems Inc. Antibioticos Ltd.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/1340417
http://linked.open.../drugbank/synonym	Anti EGFR (en) IMC-C225 (en)
http://linked.open...drugbank/toxicity	Single doses of cetuximab higher than 500 mg/m<sup>2</sup> have not been tested. There is no experience with overdosage in human clinical trials. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0422675
foaf:page	http://www.drugs.com/cdi/cetuximab.html http://www.rxlist.com/cgi/generic3/erbitux.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B3E85-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B3E84-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Cetuximab
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	205923-56-4 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B3E82-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B3E83-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B3E81-363D-11E5-9242-09173F13E4C5

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