About: Altered Astrocytic Swelling in the Cortex of α-Syntrophin-Negative GFAP/EGFP Mice     Goto   Sponge   NotDistinct   Permalink

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  • In the present study we quantified cell volume changes in astrocytes lacking α-syntrophin thanks to the successful generation of GFAP/EGFP/α-Syn-/- mice, which enabled us to visualize astrocytes based on EGFP expression. We demonstrated that α-syntrophin knockout results in smaller astrocytic swelling when induced by severe hypoosmotic stress, OGD or high extracellular K+, and it also affects astrocyte volume changes during the washout period following mild hypo- and hyperosmotic stress, and 10 mMK+.
  • In the present study we quantified cell volume changes in astrocytes lacking α-syntrophin thanks to the successful generation of GFAP/EGFP/α-Syn-/- mice, which enabled us to visualize astrocytes based on EGFP expression. We demonstrated that α-syntrophin knockout results in smaller astrocytic swelling when induced by severe hypoosmotic stress, OGD or high extracellular K+, and it also affects astrocyte volume changes during the washout period following mild hypo- and hyperosmotic stress, and 10 mMK+. (en)
Title
  • Altered Astrocytic Swelling in the Cortex of α-Syntrophin-Negative GFAP/EGFP Mice
  • Altered Astrocytic Swelling in the Cortex of α-Syntrophin-Negative GFAP/EGFP Mice (en)
skos:prefLabel
  • Altered Astrocytic Swelling in the Cortex of α-Syntrophin-Negative GFAP/EGFP Mice
  • Altered Astrocytic Swelling in the Cortex of α-Syntrophin-Negative GFAP/EGFP Mice (en)
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  • RIV/86652036:_____/14:00436669!RIV15-GA0-86652036
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  • I, P(ED1.1.00/02.0109), P(GA13-02154S), P(GBP304/12/G069)
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  • 11
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  • 2243
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  • RIV/86652036:_____/14:00436669
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  • astrocyte volume regulation; aquaporines; extracellular space (en)
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  • US - Spojené státy americké
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  • [8FE3736D6CEA]
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  • PLoS ONE
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  • 9
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  • Benešová, Jana
  • Kubista, Mikael
  • Vargová, L.
  • Anděrová, Miroslava
  • Džamba, Dávid
  • Honsa, Pavel
  • Butenko, Olena
  • Valihrach, Lukáš
  • Mikešová, Michaela
  • Cicanič, M.
  • Dmytrenko, L.
  • Kriška, Ján
  • Novosadová, Vendula
http://linked.open...ain/vavai/riv/wos
  • 000349145400053
issn
  • 1932-6203
number of pages
http://bibframe.org/vocab/doi
  • 10.1371/journal.pone.0113444
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