About: Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells     Goto   Sponge   NotDistinct   Permalink

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  • Vitamin E (VE) analogues, epitomised by the prototypic alpha-tocopheryl succinate (alpha-TOS), are potent anti-cancer agents. alpha-TOS has recently been shown to trigger apoptosis by targeting the ubiquinone (UbQ) binding site(s) of the mitochondrial complex II (CII) and to cause excessive production of reactive oxygen species. We have modelled, using two approaches, a range of VE analogues into the proximal UbQ (Q(P)) binding site of CII. This study reveals that in both cases, the calculated interaction energies of individual VE analogues correlate (R(2) value >0.8) with their toxicity to cancer cells. These data further support the UbQ site(s) of CII as an important target determining the anti-cancer activity of VE analogues as well as other emerging anti-cancer drugs.
  • Vitamin E (VE) analogues, epitomised by the prototypic alpha-tocopheryl succinate (alpha-TOS), are potent anti-cancer agents. alpha-TOS has recently been shown to trigger apoptosis by targeting the ubiquinone (UbQ) binding site(s) of the mitochondrial complex II (CII) and to cause excessive production of reactive oxygen species. We have modelled, using two approaches, a range of VE analogues into the proximal UbQ (Q(P)) binding site of CII. This study reveals that in both cases, the calculated interaction energies of individual VE analogues correlate (R(2) value >0.8) with their toxicity to cancer cells. These data further support the UbQ site(s) of CII as an important target determining the anti-cancer activity of VE analogues as well as other emerging anti-cancer drugs. (en)
Title
  • Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells
  • Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells (en)
skos:prefLabel
  • Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells
  • Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells (en)
skos:notation
  • RIV/86652036:_____/11:00369496!RIV12-AV0-86652036
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
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  • Z(AV0Z50520701)
http://linked.open...iv/cisloPeriodika
  • 10
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  • 184818
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  • RIV/86652036:_____/11:00369496
http://linked.open...riv/jazykVysledku
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  • Vitamin E analogues; mitochondrial complex II; modelling (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [B494CEDC48E0]
http://linked.open...i/riv/nazevZdroje
  • Molecular Nutrition & Food Research
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  • 55
http://linked.open...iv/tvurceVysledku
  • Dong, L.-F.
  • Dyason, J. C.
  • Neužil, Jiří
  • Ralph, S. J.
  • Černý, Jiří
http://linked.open...ain/vavai/riv/wos
  • 000296547700012
http://linked.open...n/vavai/riv/zamer
issn
  • 1613-4125
number of pages
http://bibframe.org/vocab/doi
  • 10.1002/mnfr.201100066
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