About: The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection?

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection? Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Recent research has shown that tumors contain a small subpopulation of stem-like cells that are more resistant to therapy and that are likely to produce second-line tumors. Cancer stem-like cells (CSCs) have been characterized by a variety of markers, including the plasma membrane protein CD133, which is also indicative of the increase of stemness of cultured cancer cells growing as spheres. While the function of this protein has not yet been clearly defined, it may have a role in the stem-like phenotype of CSCs that cause (re-)initiation of tumors as well as their propagation. We hypothesize that CD133 selects for CSC survival against not only immunosurveillance mechanisms but also stress-induced apoptosis. High level of expression of CD133 may be a useful marker of more aggressive tumors that are recalcitrant toward established therapies. Compelling preliminary data indicate that drugs targeting mitochondria may be utilized as a novel, efficient cancer therapeutic modality. Recent research has shown that tumors contain a small subpopulation of stem-like cells that are more resistant to therapy and that are likely to produce second-line tumors. Cancer stem-like cells (CSCs) have been characterized by a variety of markers, including the plasma membrane protein CD133, which is also indicative of the increase of stemness of cultured cancer cells growing as spheres. While the function of this protein has not yet been clearly defined, it may have a role in the stem-like phenotype of CSCs that cause (re-)initiation of tumors as well as their propagation. We hypothesize that CD133 selects for CSC survival against not only immunosurveillance mechanisms but also stress-induced apoptosis. High level of expression of CD133 may be a useful marker of more aggressive tumors that are recalcitrant toward established therapies. Compelling preliminary data indicate that drugs targeting mitochondria may be utilized as a novel, efficient cancer therapeutic modality. (en)
Title	The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection? The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection? (en)
skos:prefLabel	The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection? The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection? (en)
skos:notation	RIV/86652036:_____/11:00369486!RIV12-AV0-86652036
http://linked.open...avai/predkladatel	Biotechnologický ústav AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/08/0811), P(GA305/07/1008), Z(AV0Z50520701)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Zobalová, Renata Prokopová, Kateřina Neužil, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biotechnologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	222048
http://linked.open...ai/riv/idVysledku	RIV/86652036:_____/11:00369486
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cancer stem-like cells; protein CD133; apoptosis (en)
http://linked.open.../riv/klicoveSlovo	Cancer stem-like cells protein CD133 apoptosis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[33CFEED411D9]
http://linked.open...i/riv/nazevZdroje	Antioxidants & Redox Signaling
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanism of ROS generation and mitochondrial permeabilization Role of mitochondria in cardiomyocyte apoptosis during myocardial infarction: from cells to the whole animal
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Dong, L.-F. Neužil, Jiří Ralph, S. J. Prokopová, Kateřina Stantic, M. Stapelberg, M. Zobalová, Renata Akporiaye, E.
http://linked.open...ain/vavai/riv/wos	000296588900006
http://linked.open...n/vavai/riv/zamer	Establishing of the Biotechnology Institute ASCR
issn	1523-0864
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1089/ars.2010.3785
is http://linked.open...avai/riv/vysledek of	The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection? The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection?

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software