About: Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Mitochondria are emerging as idealized targets for anti-cancer drugs. Although they are inherent to all cells, drugs are being developed that selectively target the mitochondria of malignant cells without adversely affecting normal cells. Such anti-cancer drugs destabilizing mitochondria are referred to as mitocans, classified into several groups according to their mode of action and the location or nature of their specific targets. Many mitocans selectively interfere with the functions of cancer cell mitochondria, causing major disruptions often associated with overloads in ROS production leading to the induction of apoptosis. A common theme emerging is that mitochondrially mediated ROS activation as an apoptosis trigger offers a powerful basis for cancer therapy. Continued research is likely to identify increasing numbers of novel agents that should prove highly effective against a variety of cancers, circumventing tumor resistance to the other more established approaches Mitochondria are emerging as idealized targets for anti-cancer drugs. Although they are inherent to all cells, drugs are being developed that selectively target the mitochondria of malignant cells without adversely affecting normal cells. Such anti-cancer drugs destabilizing mitochondria are referred to as mitocans, classified into several groups according to their mode of action and the location or nature of their specific targets. Many mitocans selectively interfere with the functions of cancer cell mitochondria, causing major disruptions often associated with overloads in ROS production leading to the induction of apoptosis. A common theme emerging is that mitochondrially mediated ROS activation as an apoptosis trigger offers a powerful basis for cancer therapy. Continued research is likely to identify increasing numbers of novel agents that should prove highly effective against a variety of cancers, circumventing tumor resistance to the other more established approaches (en)
Title	Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger (en)
skos:prefLabel	Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger (en)
skos:notation	RIV/86652036:_____/10:00349341!RIV11-AV0-86652036
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50520701)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Neužil, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biotechnologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	248862
http://linked.open...ai/riv/idVysledku	RIV/86652036:_____/10:00349341
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Mitocans; reactive oxygen species; anti-cancer drugs (en)
http://linked.open.../riv/klicoveSlovo	anti-cancer drugs Mitocans reactive oxygen species
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[5143C7EE0020]
http://linked.open...i/riv/nazevZdroje	Molecular Aspects of Medicine
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Neužil, Jiří Ralph, S. J. Moreno-Sanchez, R. Rodriguez-Enriquez, S.
http://linked.open...ain/vavai/riv/wos	000276729700003
http://linked.open...n/vavai/riv/zamer	Establishing of the Biotechnology Institute ASCR
issn	0098-2997
number of pages	31 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software