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  • The aim of the study was the comparison of photo-activity of three types of titanium dioxide (TiO2) micro-dispersions intended for use as UV filters for cosmetic sunscreen products. The dispersions were also investigated with regard to their influence on the stability of photo-protective systems in cosmetic emulsions, their skin penetration/absorption and their photo-toxicity for humans and skin bacterial flora. All the tested micro-dispersions of rutile TiO2 type (agglomerates with diameter 120-150 nm), with primary particle size lower than 100 nm, demonstrated no phototoxic effect and insignificant antimicrobial behaviour. On the other hand, TiO2 with insufficient deactivation of photo-activity had significant negative impact on the stability of other organic UV filters and therefore on the stability of declared UV protective factors (SPF, UVA-PF). The study demonstrated that the level of deactivation of TiO2 is one of the highly important factors for evaluation of UV filters used as sunscreens.
  • The aim of the study was the comparison of photo-activity of three types of titanium dioxide (TiO2) micro-dispersions intended for use as UV filters for cosmetic sunscreen products. The dispersions were also investigated with regard to their influence on the stability of photo-protective systems in cosmetic emulsions, their skin penetration/absorption and their photo-toxicity for humans and skin bacterial flora. All the tested micro-dispersions of rutile TiO2 type (agglomerates with diameter 120-150 nm), with primary particle size lower than 100 nm, demonstrated no phototoxic effect and insignificant antimicrobial behaviour. On the other hand, TiO2 with insufficient deactivation of photo-activity had significant negative impact on the stability of other organic UV filters and therefore on the stability of declared UV protective factors (SPF, UVA-PF). The study demonstrated that the level of deactivation of TiO2 is one of the highly important factors for evaluation of UV filters used as sunscreens. (en)
Title
  • Characteristics of titanium dioxide microdispersions with different photo-activity suitable for sunscreen formulations
  • Characteristics of titanium dioxide microdispersions with different photo-activity suitable for sunscreen formulations (en)
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  • Characteristics of titanium dioxide microdispersions with different photo-activity suitable for sunscreen formulations
  • Characteristics of titanium dioxide microdispersions with different photo-activity suitable for sunscreen formulations (en)
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  • RIV/75010330:_____/15:00010725!RIV15-TA0-75010330
http://linked.open...avai/riv/aktivita
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  • P(NT14060), P(TA01010613)
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  • 1-2
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  • 62
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  • RIV/75010330:_____/15:00010725
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  • UV radiation; UV filter; titanium dioxide; phototoxicity; microdispersion (en)
http://linked.open.../riv/klicoveSlovo
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  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [8A94D3F559B1]
http://linked.open...i/riv/nazevZdroje
  • International Journal of Pharmaceutics
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  • 481
http://linked.open...iv/tvurceVysledku
  • Bendová, Hana
  • Hladíková, Zuzana
  • Jírová, Dagmar
  • Kejlová, Kristina
  • Kubáč, L.
  • Klánová, Kateřina
  • Kašparová, Lucie
  • Akrman, J.
  • Kovaříková, L.
  • Pikal, P.
http://linked.open...ain/vavai/riv/wos
  • 000350453600012
issn
  • 0378-5173
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.ijpharm.2015.02.004
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