About: Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: a qualitative and quantitative assessment     Goto   Sponge   NotDistinct   Permalink

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Description
  • A novel multicomponent vaccine against meningococcal capsular group B (MenB) disease contains four major components: factor-H-binding protein, neisserial heparin binding antigen, neisserial adhesin A, and outer-membrane vesicles derived from the strain NZ98/254. Because the public health effect of the vaccine, 4CMenB (Novartis Vaccines and Diagnostics, Siena, Italy), is unclear, we assessed the predicted strain coverage in Europe. MATS (Meningococcal antigen typing system) analysis showed that a multicomponent vaccine could protect against a substantial proportion of invasive MenB strains isolated in Europe. Monitoring of antigen expression, however, will be needed in the future.
  • A novel multicomponent vaccine against meningococcal capsular group B (MenB) disease contains four major components: factor-H-binding protein, neisserial heparin binding antigen, neisserial adhesin A, and outer-membrane vesicles derived from the strain NZ98/254. Because the public health effect of the vaccine, 4CMenB (Novartis Vaccines and Diagnostics, Siena, Italy), is unclear, we assessed the predicted strain coverage in Europe. MATS (Meningococcal antigen typing system) analysis showed that a multicomponent vaccine could protect against a substantial proportion of invasive MenB strains isolated in Europe. Monitoring of antigen expression, however, will be needed in the future. (en)
Title
  • Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: a qualitative and quantitative assessment
  • Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: a qualitative and quantitative assessment (en)
skos:prefLabel
  • Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: a qualitative and quantitative assessment
  • Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: a qualitative and quantitative assessment (en)
skos:notation
  • RIV/75010330:_____/13:00010108!RIV14-MZ0-75010330
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 98553
http://linked.open...ai/riv/idVysledku
  • RIV/75010330:_____/13:00010108
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Neisseria meningitidis; vaccination; vaccine 4CMenB; surveillance; antibodies; randomized controlled trial (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [1297387F9DA5]
http://linked.open...i/riv/nazevZdroje
  • Lancet infectious diseases
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 13
http://linked.open...iv/tvurceVysledku
  • Křížová, Pavla
  • Musílek, Martin
  • Caugant, D. A.
  • Frosch, M.
  • Taha, M. K.
  • Claus, H.
  • Vogel, U.
  • Abad, R.
  • Borrow, R.
  • Deghmane, A. E.
  • Findlow, J.
  • Vazquez, J. A
  • Bambini, S.
  • Boccadifuoco, G.
  • Carannante, A.
  • Comanducci, M.
  • Donnelly, J. J.
  • Fazio, C.
  • Frosi, G.
  • Gilchrist, S.
  • Giuliani, M. M.
  • Hong, E.
  • Ledroit, M.
  • Lovaglio, P. G.
  • Lucidarme, J.
  • Medini, D.
  • Muzzi, A.
  • Oksnes, J.
  • Orlandi, L.
  • Pizza, M.
  • Rappuoli, R.
  • Rigat, F.
  • Serruto, D.
  • Stefanelli, P.
  • Stella, M.
  • Thompson, D.
http://linked.open...ain/vavai/riv/wos
  • 000319534400024
issn
  • 1473-3099
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/S1473-3099(13)70006-9
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