About: Influence of the combination and phase variation status of the haemoglobin receptors HmbR and HpuAB on meningococcal virulence

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About: Influence of the combination and phase variation status of the haemoglobin receptors HmbR and HpuAB on meningococcal virulence Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Neisseria meningitidis can utilize haem, haemoglobin and haemoglobin-haptoglobin complexes as sources of iron via two TonB-dependent phase variable haemoglobin receptors, HmbR and HpuAB. This study compared the distribution of HpuAB and phase variation (PV) status of both receptors in disease and carriage isolates. We suggest that expression of a haemoglobin receptor, either HmbR or HpuAB, is of major importance for systemic spread of meningococci, and that the presence of both receptors contributes to virulence in some strains. Neisseria meningitidis can utilize haem, haemoglobin and haemoglobin-haptoglobin complexes as sources of iron via two TonB-dependent phase variable haemoglobin receptors, HmbR and HpuAB. This study compared the distribution of HpuAB and phase variation (PV) status of both receptors in disease and carriage isolates. We suggest that expression of a haemoglobin receptor, either HmbR or HpuAB, is of major importance for systemic spread of meningococci, and that the presence of both receptors contributes to virulence in some strains. (en)
Title	Influence of the combination and phase variation status of the haemoglobin receptors HmbR and HpuAB on meningococcal virulence Influence of the combination and phase variation status of the haemoglobin receptors HmbR and HpuAB on meningococcal virulence (en)
skos:prefLabel	Influence of the combination and phase variation status of the haemoglobin receptors HmbR and HpuAB on meningococcal virulence Influence of the combination and phase variation status of the haemoglobin receptors HmbR and HpuAB on meningococcal virulence (en)
skos:notation	RIV/75010330:_____/11:00009390!RIV12-MZ0-75010330
http://linked.open...avai/predkladatel	Státní zdravotní ústav
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Křížová, Pavla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Státní zdravotní ústav, příspěvková organizace
http://linked.open...dnocenehoVysledku	204625
http://linked.open...ai/riv/idVysledku	RIV/75010330:_____/11:00009390
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Neisseria meningitidis; virulence; haemoglobin (en)
http://linked.open.../riv/klicoveSlovo	haemoglobin Neisseria meningitidis virulence
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C5E44841B2A0]
http://linked.open...i/riv/nazevZdroje	Microbiology-SGM
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	157
http://linked.open...iv/tvurceVysledku	Křížová, Pavla Ala'Aldeen, D.A.A. Bayliss, C. D. Feavers, I. M. Gray, S. Harrison, O. B. Maiden, M. C. J. Neal, K. R. Tauseef, I. Turner, D.P.J. Wooldridge, K. G.
http://linked.open...ain/vavai/riv/wos	000291179900019
issn	1350-0872
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Influence of the combination and phase variation status of the haemoglobin receptors HmbR and HpuAB on meningococcal virulence Influence of the combination and phase variation status of the haemoglobin receptors HmbR and HpuAB on meningococcal virulence

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