About: Genetic variability of cytomegalovirus glycoprotein O in hematopoietic stem cell transplant recipients

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Genetic variation of cytomegalovirus (CMV) strains can correlate with their pathogenicity for immunocompromised patients. Glycoprotein O (gO), together with glycoprotein L and glycoprotein H, mediate the fusion of the viral envelope with the cell membrane and promotes virus penetration, envelopment, and release. The variability of gO might play a role in CMV cell tropism. The goal was a retrospective analysis of gO variability in a cohort of hematopoietic stem cell transplant (HSCT) recipients to determine the distribution of gO genotypes and to investigate their impact on clinical outcome and manifestation of CMV infection. gO genotyping may contribute to the biological characterization of CMV strains in HSCT recipients. Genetic variation of cytomegalovirus (CMV) strains can correlate with their pathogenicity for immunocompromised patients. Glycoprotein O (gO), together with glycoprotein L and glycoprotein H, mediate the fusion of the viral envelope with the cell membrane and promotes virus penetration, envelopment, and release. The variability of gO might play a role in CMV cell tropism. The goal was a retrospective analysis of gO variability in a cohort of hematopoietic stem cell transplant (HSCT) recipients to determine the distribution of gO genotypes and to investigate their impact on clinical outcome and manifestation of CMV infection. gO genotyping may contribute to the biological characterization of CMV strains in HSCT recipients. (en)
Title	Genetic variability of cytomegalovirus glycoprotein O in hematopoietic stem cell transplant recipients Genetic variability of cytomegalovirus glycoprotein O in hematopoietic stem cell transplant recipients (en)
skos:prefLabel	Genetic variability of cytomegalovirus glycoprotein O in hematopoietic stem cell transplant recipients Genetic variability of cytomegalovirus glycoprotein O in hematopoietic stem cell transplant recipients (en)
skos:notation	RIV/75010330:_____/11:00009081!RIV13-MZ0-75010330
http://linked.open...avai/predkladatel	Státní zdravotní ústav
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR9418), Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Procházka, Bohumír Žufanová, Světlana Strunecký, Otakar
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Státní zdravotní ústav, příspěvková organizace
http://linked.open...dnocenehoVysledku	201011
http://linked.open...ai/riv/idVysledku	RIV/75010330:_____/11:00009081
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cytomegalovirus; CMV; genotypes; transplantation; stem cells (en)
http://linked.open.../riv/klicoveSlovo	stem cells CMV cytomegalovirus genotypes transplantation
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D81EA8ADACD0]
http://linked.open...i/riv/nazevZdroje	Transplant infectious disease
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Utilisation of genetical analysis to the diagnostics of human cytomegalovirus infection in immunodeficient patients
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	13
http://linked.open...iv/tvurceVysledku	Procházka, Bohumír Roubalová, K. Strunecký, Otakar Vítek, A. Žufanová, Světlana
http://linked.open...ain/vavai/riv/wos	000291231500003
http://linked.open...n/vavai/riv/zamer	Význam molekulárně biologických vyšetření pro objasnění patogeneze a pro diagnostiku poruch krvetvorby a využití krvetvorné buňky v léčbě onemocnění krvetvorby a jiných tkání.
issn	1398-2273
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1399-3062.2011.00625.x
is http://linked.open...avai/riv/vysledek of	Genetic variability of cytomegalovirus glycoprotein O in hematopoietic stem cell transplant recipients

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