About: The influence of quarternary salt on hyaluronan conformation and particle size in solution     Goto   Sponge   NotDistinct   Permalink

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  • Interaction of hyaluronan (NaHy) with the quaternary salt, benzalkonium chloride (BAC), was studied. Based on the DLS experiments, viscometry and surface tension measurements executed on hyaluronan samples with two molecular weights of Mw = 1.8 MDa and Mw = 0.35 MDa, the hypothesis was proposed suggesting that at certain BAC concentrations, hyaluronan can form aggregates, which lead to increase of the polymer coil size measured as z-average diameter. Moreover, it was confirmed that within the whole range of BAC concentrations, repeated variations in size and conformations of polymer coils occur, being connected with the critical micellar concentration of BAC and with hydrophobic interactions of nonpolar segments of BAC with hyaluronan hydrophobic domains. Tensiometry, DLS and viscometry data support the assumption that variations of thermodynamical %22favourability%22 of BAC-BAC or NaHy-BAC interactions take place in hyaluronan solutions, based on the BAC concentration.
  • Interaction of hyaluronan (NaHy) with the quaternary salt, benzalkonium chloride (BAC), was studied. Based on the DLS experiments, viscometry and surface tension measurements executed on hyaluronan samples with two molecular weights of Mw = 1.8 MDa and Mw = 0.35 MDa, the hypothesis was proposed suggesting that at certain BAC concentrations, hyaluronan can form aggregates, which lead to increase of the polymer coil size measured as z-average diameter. Moreover, it was confirmed that within the whole range of BAC concentrations, repeated variations in size and conformations of polymer coils occur, being connected with the critical micellar concentration of BAC and with hydrophobic interactions of nonpolar segments of BAC with hyaluronan hydrophobic domains. Tensiometry, DLS and viscometry data support the assumption that variations of thermodynamical %22favourability%22 of BAC-BAC or NaHy-BAC interactions take place in hyaluronan solutions, based on the BAC concentration. (en)
Title
  • The influence of quarternary salt on hyaluronan conformation and particle size in solution
  • The influence of quarternary salt on hyaluronan conformation and particle size in solution (en)
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  • The influence of quarternary salt on hyaluronan conformation and particle size in solution
  • The influence of quarternary salt on hyaluronan conformation and particle size in solution (en)
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  • RIV/70883521:28610/13:43869709!RIV14-MSM-28610___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
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  • P(ED2.1.00/03.0111), S
http://linked.open...iv/cisloPeriodika
  • 1
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http://linked.open...aciTvurceVysledku
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  • 79898
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  • RIV/70883521:28610/13:43869709
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  • Critical micellar concentration||Dynamic light scattering||Hyaluronan||Hyaluronan conformation||Hyaluronan hydrophobic interactions||Quarternary salts (en)
http://linked.open.../riv/klicoveSlovo
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  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [35D747460107]
http://linked.open...i/riv/nazevZdroje
  • Carbohydrate Polymers
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  • 98
http://linked.open...iv/tvurceVysledku
  • Kašpárková, Věra
  • Minařík, Antonín
  • Mráček, Aleš
  • Smolka, Petr
  • Gřundělová, Lenka
http://linked.open...ain/vavai/riv/wos
  • 000325835600136
issn
  • 0144-8617
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.carbpol.2013.06.057
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  • 28610
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