About: The molecular mechanism of selected pathological processes in the cell

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About: The molecular mechanism of selected pathological processes in the cell - Metabolism of silybin- a review Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Silymarin, a standard extract from Silybum marianum L. seeds, contains at least 7 flavonolignans and flavonoid taxifolin. It has been used to date, as a hepatoprotectant and chemoprotectant. Flavonolignan silybin, the main component of silymarin, is composed of two diastereomers A and B in an approximately 1:1 ratio. Silybin can inhibit the activities of cytochrome P450 enzymes (CYP) (Beckmann-Knopp S. et al., 2000). In our study, the most prominent inhibition effect was found with CYP3A4 and CYP2C9 (IC50 <= 50 μM). In the second part of our study, the metabolism of silybin in vitro was analyzed in detail. The results indicated that silybin is subjected to O-demethylation by CYP2C8, enzymes of Phase I in xenobiotic metabolism. The contribution of UDP-glucuronosyltransferases (main phase II enzymes) to the metabolism of silybin and its A and B diastereomers was also investigated. Four main metabolites of silybin, namely silybin A-7-O-β-D-glucuronide, B-7-O-β-D-glucuronide, A-20-O Silymarin, a standard extract from Silybum marianum L. seeds, contains at least 7 flavonolignans and flavonoid taxifolin. It has been used to date, as a hepatoprotectant and chemoprotectant. Flavonolignan silybin, the main component of silymarin, is composed of two diastereomers A and B in an approximately 1:1 ratio. Silybin can inhibit the activities of cytochrome P450 enzymes (CYP) (Beckmann-Knopp S. et al., 2000). In our study, the most prominent inhibition effect was found with CYP3A4 and CYP2C9 (IC50 <= 50 μM). In the second part of our study, the metabolism of silybin in vitro was analyzed in detail. The results indicated that silybin is subjected to O-demethylation by CYP2C8, enzymes of Phase I in xenobiotic metabolism. The contribution of UDP-glucuronosyltransferases (main phase II enzymes) to the metabolism of silybin and its A and B diastereomers was also investigated. Four main metabolites of silybin, namely silybin A-7-O-β-D-glucuronide, B-7-O-β-D-glucuronide, A-20-O (en)
Title	The molecular mechanism of selected pathological processes in the cell - Metabolism of silybin- a review The molecular mechanism of selected pathological processes in the cell - Metabolism of silybin- a review (en)
skos:prefLabel	The molecular mechanism of selected pathological processes in the cell - Metabolism of silybin- a review The molecular mechanism of selected pathological processes in the cell - Metabolism of silybin- a review (en)
skos:notation	RIV/70883521:28110/10:63510150!RIV11-MSM-28110___
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Jančová, Petra
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Tomáše Bati ve Zlíně / Fakulta technologická
http://linked.open...dnocenehoVysledku	272389
http://linked.open...ai/riv/idVysledku	RIV/70883521:28110/10:63510150
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	silybin; metabolism; cytochromes P450; UDP glucuronosyltransferases (en)
http://linked.open.../riv/klicoveSlovo	UDP glucuronosyltransferases metabolism cytochromes P450 silybin
http://linked.open...ontrolniKodProRIV	[BE85562E618C]
http://linked.open...v/mistoKonaniAkce	Vyškov
http://linked.open...i/riv/mistoVydani	Olomouc
http://linked.open...i/riv/nazevZdroje	Biomedical Papers of the Faculty of Medicine of Palacký University in Olomouc
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Křen, Vladimír Lemr, Karel Papoušková, Barbora Anzenbacher, Pavel Anzenbacherová, Eva Jančová, Petra Tunková, Alena Šiller, Michal Lužná, Pavla Šimánek, Vilém
http://linked.open...vavai/riv/typAkce	CST - Celostátní
http://linked.open.../riv/zahajeniAkce	2010-01-01 (xsd:date)
issn	1213-8118
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Univerzita Palackého v Olomouci
http://localhost/t...ganizacniJednotka	28110
is http://linked.open...avai/riv/vysledek of	The molecular mechanism of selected pathological processes in the cell - Metabolism of silybin- a review The molecular mechanism of selected pathological processes in the cell - Metabolism of silybin- a review The molecular mechanism of selected pathological processes in the cell - Metabolism of silybin- a review

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