About: Characterization of Yersinia using MALDI-TOF mass spectrometry and chemometrics

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Classification analysis by supervised artificial neural networks allowed identification of strains of Y. pestis with an accuracy of 100%. In-depth analysis of proteomic data demonstrated the existence of Yersinia-specific biomarkers at m/z 4350 and 6046. In addition, we could also identify species-specific biomarkers of Y. enterocolitica at m/z 7262, 9238, and 9608. For Y. pseudotuberculosis a combination of biomarkers at m/z 6474, 7274, and 9268 turned out to be specific, while a peak combination at m/z 3065, 6637, and 9659 was characteristic for strains of Y. pestis. Bioinformatic approaches and tandem mass spectrometry were employed to reveal the molecular identity of biomarker ions. In this way, the Y. pestis-specific biomarker at m/z 3065 could be identified as a fragment of the plasmid-encoded plasminogen activator, one of the major virulence factors in plague infections. Classification analysis by supervised artificial neural networks allowed identification of strains of Y. pestis with an accuracy of 100%. In-depth analysis of proteomic data demonstrated the existence of Yersinia-specific biomarkers at m/z 4350 and 6046. In addition, we could also identify species-specific biomarkers of Y. enterocolitica at m/z 7262, 9238, and 9608. For Y. pseudotuberculosis a combination of biomarkers at m/z 6474, 7274, and 9268 turned out to be specific, while a peak combination at m/z 3065, 6637, and 9659 was characteristic for strains of Y. pestis. Bioinformatic approaches and tandem mass spectrometry were employed to reveal the molecular identity of biomarker ions. In this way, the Y. pestis-specific biomarker at m/z 3065 could be identified as a fragment of the plasmid-encoded plasminogen activator, one of the major virulence factors in plague infections. (en)
Title	Characterization of Yersinia using MALDI-TOF mass spectrometry and chemometrics Characterization of Yersinia using MALDI-TOF mass spectrometry and chemometrics (en)
skos:prefLabel	Characterization of Yersinia using MALDI-TOF mass spectrometry and chemometrics Characterization of Yersinia using MALDI-TOF mass spectrometry and chemometrics (en)
skos:notation	RIV/70565813:_____/10:#0000207!RIV11-MO0-70565813
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(OVUOFVZ200901)
http://linked.open...iv/cisloPeriodika	20
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Dřevínek, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Státní ústav jaderné, chemické a biologické ochrany, v.v.i.
http://linked.open...dnocenehoVysledku	250461
http://linked.open...ai/riv/idVysledku	RIV/70565813:_____/10:#0000207
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Yersinia; MALDI-TOF (en)
http://linked.open.../riv/klicoveSlovo	MALDI-TOF Yersinia
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9A17927A2AEC]
http://linked.open...i/riv/nazevZdroje	Analytical Chemistry
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Classification of biological agents – support of an international project „Establishment and management of a common database of B-agents – A European Laboratory Biodefence Network
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	82
http://linked.open...iv/tvurceVysledku	Dřevínek, Michal Lasch, Peter
issn	0003-2700
number of pages	12 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Characterization of Yersinia using MALDI-TOF mass spectrometry and chemometrics Characterization of Yersinia using MALDI-TOF mass spectrometry and chemometrics Characterization of Yersinia using MALDI-TOF mass spectrometry and chemometrics

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