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| rdf:type
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| Description
| - Ischemia-related processes, including electrophysiological alterations, are associated with the generation of reactive oxygen species. Although the cardioprotective action of antioxidants against ischemic injury has been proposed, their electrophysiological effects are not clear. The aim of this study was to investigate the effects of the antioxidant Echinochrome on ischemia-induced alterations of ventricular repolarization in a feline model of coronary occlusion. Experiments were performed on open-chest anesthetized adult cats. Activation-recovery intervals were measured from 64 ventricular epicardial unipolar electrograms recorded simultaneously before and during ligation of the left anterior descending coronary artery. Synthetic Echinochrome was infused five minutes before coronary occlusion in two different doses (1.0 mg/kg and 2.0 mg/kg, i.v.). Pre-occlusion administration of Echinochrome in a dose of 1.0 mg/kg resulted in the reduction of ischemiainduced shortening of activation-recovery intervals and the restricted increase in the repolarization dispersion during 30 minutes of ischemia. Echinochrome in a dose of 2.0 mg/kg demonstrated a more pronounced effect. Ability of the antioxidant Echinochrome to decrease ischemia-induced alterations of ventricular repolarization was demonstrated in a feline model of coronary occlusion. A dose-dependent effect was suggested.
- Ischemia-related processes, including electrophysiological alterations, are associated with the generation of reactive oxygen species. Although the cardioprotective action of antioxidants against ischemic injury has been proposed, their electrophysiological effects are not clear. The aim of this study was to investigate the effects of the antioxidant Echinochrome on ischemia-induced alterations of ventricular repolarization in a feline model of coronary occlusion. Experiments were performed on open-chest anesthetized adult cats. Activation-recovery intervals were measured from 64 ventricular epicardial unipolar electrograms recorded simultaneously before and during ligation of the left anterior descending coronary artery. Synthetic Echinochrome was infused five minutes before coronary occlusion in two different doses (1.0 mg/kg and 2.0 mg/kg, i.v.). Pre-occlusion administration of Echinochrome in a dose of 1.0 mg/kg resulted in the reduction of ischemiainduced shortening of activation-recovery intervals and the restricted increase in the repolarization dispersion during 30 minutes of ischemia. Echinochrome in a dose of 2.0 mg/kg demonstrated a more pronounced effect. Ability of the antioxidant Echinochrome to decrease ischemia-induced alterations of ventricular repolarization was demonstrated in a feline model of coronary occlusion. A dose-dependent effect was suggested. (en)
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| Title
| - Effects of Echinochrome on Ventricular Repolarization in Acute Ischemia
- Effects of Echinochrome on Ventricular Repolarization in Acute Ischemia (en)
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| skos:prefLabel
| - Effects of Echinochrome on Ventricular Repolarization in Acute Ischemia
- Effects of Echinochrome on Ventricular Repolarization in Acute Ischemia (en)
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| skos:notation
| - RIV/68407700:21460/14:00218888!RIV15-MSM-21460___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68407700:21460/14:00218888
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Cardiac Electrophysiology; Repolarization; Ischemia; Antioxidant; Animal Model (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...v/mistoKonaniAkce
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
| - Electrocardiology 2014 Proceedings
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...iv/tvurceVysledku
| - Sedova, Ksenia
- Bernikova, O.
- Kharin, S.
- Shmakov, D.
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| http://linked.open...vavai/riv/typAkce
| |
| http://linked.open.../riv/zahajeniAkce
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| number of pages
| |
| http://purl.org/ne...btex#hasPublisher
| - Institute of Measurement Science
|
| https://schema.org/isbn
| |
| http://localhost/t...ganizacniJednotka
| |
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