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  • Alzheimer's disease is one of the major neurodegenerative diseases; the elderly population is affected (about 50% at age 85 years). Manifested by memory loss, impairedspeech and worsening of orientation change of personality. According to some research on the emergence and development of the involved metabolites produced in the digestive tract, resulting in a hypothesis concerning the proportion of microbial activity in the etiology of this disease. Comparison of faecal microflora composition differences in healthy people and patients should contribude to understanding the etiology and pathogenesis of the disease. Real Time PCR was used to monitor possible changes in the levels of total bacteria and the levels of individual bacterial groups: Bifidobacteria, Clostridium leptum, Enterobacteriaceae, Lactobacillus- Streptococcus-Enterobacter, and Bacteroides- Prevotella. The DGGE profiles revealed the great complexity and specificity of eachtest subjects and changes in the composition of samples that have been observed.
  • Alzheimer's disease is one of the major neurodegenerative diseases; the elderly population is affected (about 50% at age 85 years). Manifested by memory loss, impairedspeech and worsening of orientation change of personality. According to some research on the emergence and development of the involved metabolites produced in the digestive tract, resulting in a hypothesis concerning the proportion of microbial activity in the etiology of this disease. Comparison of faecal microflora composition differences in healthy people and patients should contribude to understanding the etiology and pathogenesis of the disease. Real Time PCR was used to monitor possible changes in the levels of total bacteria and the levels of individual bacterial groups: Bifidobacteria, Clostridium leptum, Enterobacteriaceae, Lactobacillus- Streptococcus-Enterobacter, and Bacteroides- Prevotella. The DGGE profiles revealed the great complexity and specificity of eachtest subjects and changes in the composition of samples that have been observed. (en)
Title
  • Characterization of colonic microbial community in patients with Alzheimer's disease
  • Characterization of colonic microbial community in patients with Alzheimer's disease (en)
skos:prefLabel
  • Characterization of colonic microbial community in patients with Alzheimer's disease
  • Characterization of colonic microbial community in patients with Alzheimer's disease (en)
skos:notation
  • RIV/68407700:21460/12:00202757!RIV13-MSM-21460___
http://linked.open...avai/predkladatel
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  • P(EE.2.3.20.0092)
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  • 126809
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  • RIV/68407700:21460/12:00202757
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Alzheimer; neurodegenerative diseases; Bifidobacteria, bacteria; cell; DNA; , (en)
http://linked.open.../riv/klicoveSlovo
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  • [A65CF94EC510]
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  • Kladno
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  • Prague
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  • Instuments and Methods for Biology and Medicine 2012
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  • Jarošíková, Taťána
  • Šimůnek, J.
  • Křepelková, Martina
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
number of pages
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  • České vysoké učení technické v Praze
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  • 978-80-01-05119-1
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  • 21460
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