About: Nanoconstructs in Targeted Alpha-Therapy

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nanotechnology has brought brand new concept into the targeted radionuclide therapy field. Radionuclides decaying by alpha particle cascade, due to their high linear energy transfer deposit the decay energy in a very small tissue volume, usually of few cells. Main disadvantage of these radionuclides is that no chelator or other type of labelled molecule can withhold the recoil energy of daughter hot atoms generated in such decays. Every hot daughter atom is thus immediately released from the carrier molecule and may cause severe damage to healthy tissues in vivo, particularly when applied systemically. Some nanosized engineered constructs are due to their physical and chemical properties at least partially able to retain recoiled atoms and ensure proper therapeutical dose targeting. An overview of various approaches and attempts is given in this paper together with an outlook for prospective solutions and their applications. Nanotechnology has brought brand new concept into the targeted radionuclide therapy field. Radionuclides decaying by alpha particle cascade, due to their high linear energy transfer deposit the decay energy in a very small tissue volume, usually of few cells. Main disadvantage of these radionuclides is that no chelator or other type of labelled molecule can withhold the recoil energy of daughter hot atoms generated in such decays. Every hot daughter atom is thus immediately released from the carrier molecule and may cause severe damage to healthy tissues in vivo, particularly when applied systemically. Some nanosized engineered constructs are due to their physical and chemical properties at least partially able to retain recoiled atoms and ensure proper therapeutical dose targeting. An overview of various approaches and attempts is given in this paper together with an outlook for prospective solutions and their applications. (en)
Title	Nanoconstructs in Targeted Alpha-Therapy Nanoconstructs in Targeted Alpha-Therapy (en)
skos:prefLabel	Nanoconstructs in Targeted Alpha-Therapy Nanoconstructs in Targeted Alpha-Therapy (en)
skos:notation	RIV/68407700:21340/14:00223604!RIV15-MSM-21340___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(LK21310)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Kozempel, Ján Vlk, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	České vysoké učení technické v Praze / Fakulta jaderná a fyzikálně inženýrská
http://linked.open...dnocenehoVysledku	31492
http://linked.open...ai/riv/idVysledku	RIV/68407700:21340/14:00223604
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	in vivo generators; nanoconstructs, nanoparticles, targeted alpha particle therapy (en)
http://linked.open.../riv/klicoveSlovo	nanoparticles in vivo generators nanoconstructs targeted alpha particle therapy
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[7ED6D75E32CD]
http://linked.open...i/riv/nazevZdroje	Recent Patents on Nanomedicine
http://linked.open...in/vavai/riv/obor	CH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of transmutation of Ra-226 and its separation from activation products
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Vlk, Martin Kozempel, Ján
issn	1877-9123
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.2174/1877912305666150102000549
http://localhost/t...ganizacniJednotka	21340

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