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Description
| - Radium-223 is prospective alpha-emmiting therapeutic radionuclide for targeted radionuclide therapy. Although Ra-223 is formed naturally by the decay of U-235, for practical reasons its preparation involves neutron irradiation of Ra-226. The decay of Ra-227 leads to Ac-227, which decays to Th-227 and Ra-223 subsequently. Ra-226 as a decay product of U-238 is generally available in multigram quantities (mainly historical stock). Main purpose of this study was to experimentally and theoretically evaluate and verify available literature data on productionof Ra-223. According to dates obtained from gamma spectra, the yield of this irradiation and cross sections were calculated. Radium-226 sample was flame-sealed in a quartz ampoule and irradiated for 11,7 days in a neutron flow. The yield of Ra-223 and other products were determined several weeks after EOB by evaluation of gamma and alfa spectra. Less than one month after irradiation Ra-223, Pb-212, Bi-212, Tl-208 peaks can be found on gamma spectra. In three – four month the best peaks can be seen are peaks of Pb-214 and Bi-214, which are decay products of Ra-226. Also peaks of Ac-227, Th-227, Ra-223, Pb-211, Th-228 and Ra-224 can be found, but some of them are interfered by Pb-214 and Bi-214 peaks, other of them are very small in compare with Pb-214 and Bi-214. This work was partially supported by the Ministry of Education youth and sports and Technology Agency of the Czech republic, grant numbers LK21310 and TA03010027.
- Radium-223 is prospective alpha-emmiting therapeutic radionuclide for targeted radionuclide therapy. Although Ra-223 is formed naturally by the decay of U-235, for practical reasons its preparation involves neutron irradiation of Ra-226. The decay of Ra-227 leads to Ac-227, which decays to Th-227 and Ra-223 subsequently. Ra-226 as a decay product of U-238 is generally available in multigram quantities (mainly historical stock). Main purpose of this study was to experimentally and theoretically evaluate and verify available literature data on productionof Ra-223. According to dates obtained from gamma spectra, the yield of this irradiation and cross sections were calculated. Radium-226 sample was flame-sealed in a quartz ampoule and irradiated for 11,7 days in a neutron flow. The yield of Ra-223 and other products were determined several weeks after EOB by evaluation of gamma and alfa spectra. Less than one month after irradiation Ra-223, Pb-212, Bi-212, Tl-208 peaks can be found on gamma spectra. In three – four month the best peaks can be seen are peaks of Pb-214 and Bi-214, which are decay products of Ra-226. Also peaks of Ac-227, Th-227, Ra-223, Pb-211, Th-228 and Ra-224 can be found, but some of them are interfered by Pb-214 and Bi-214 peaks, other of them are very small in compare with Pb-214 and Bi-214. This work was partially supported by the Ministry of Education youth and sports and Technology Agency of the Czech republic, grant numbers LK21310 and TA03010027. (en)
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Title
| - Preparation of 223Ra by neutron irradiation of 226Ra
- Preparation of 223Ra by neutron irradiation of 226Ra (en)
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skos:prefLabel
| - Preparation of 223Ra by neutron irradiation of 226Ra
- Preparation of 223Ra by neutron irradiation of 226Ra (en)
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skos:notation
| - RIV/68407700:21340/14:00218487!RIV15-MSM-21340___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(LK21310), P(TA03010027)
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68407700:21340/14:00218487
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - 223Ra; 226Ra; irradiation; neutron (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Vopálka, Dušan
- Vlk, Martin
- Kozempel, Ján
- Mičolová, Petra
- Kukleva, Ekaterina
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http://localhost/t...ganizacniJednotka
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