About: Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas

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About: Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Inadequate cross-linking between collagens is a characteristic feature of keratoconus (KC). The formation of bonds between collagen and elastin fibrils is mediated by the lysyl oxidase (LOX) and 4 LOX-like enzymes. The aim of this study was to determine the distribution of LOX and the total LOX activity (LOX and 4 LOX-like enzymes) in control and KC corneas. The distribution of LOX was clearly decreased in at least 5 of the 8 KC specimens. The most marked signal reduction was observed in the stromal matrix and in keratocytes. The signal in KC specimens revealed a more irregular pattern. Endothelial cells showed no or very weak staining in areas just beneath negative stromal tissue. The mean activity of total LOX in the KC samples was lower than in control tissue and the decrease was statistically significant (p = 0.0178). We hypothesize that the restricted LOX distribution in KC corneas, and particularly the decrease of total LOX activity in cultured keratoconic fibroblasts, is one potential reason for the inadequate collagen cross-linking that is a hallmark of this disease. Inadequate cross-linking between collagens is a characteristic feature of keratoconus (KC). The formation of bonds between collagen and elastin fibrils is mediated by the lysyl oxidase (LOX) and 4 LOX-like enzymes. The aim of this study was to determine the distribution of LOX and the total LOX activity (LOX and 4 LOX-like enzymes) in control and KC corneas. The distribution of LOX was clearly decreased in at least 5 of the 8 KC specimens. The most marked signal reduction was observed in the stromal matrix and in keratocytes. The signal in KC specimens revealed a more irregular pattern. Endothelial cells showed no or very weak staining in areas just beneath negative stromal tissue. The mean activity of total LOX in the KC samples was lower than in control tissue and the decrease was statistically significant (p = 0.0178). We hypothesize that the restricted LOX distribution in KC corneas, and particularly the decrease of total LOX activity in cultured keratoconic fibroblasts, is one potential reason for the inadequate collagen cross-linking that is a hallmark of this disease. (en)
Title	Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas (en)
skos:prefLabel	Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas (en)
skos:notation	RIV/68407700:21340/12:00197495!RIV13-MSM-21340___
http://linked.open...avai/predkladatel	Fakulta jaderná a fyzikálně inženýrská
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(GPP301/12/P591), S, Z(MSM6840770040)
http://linked.open...iv/cisloPeriodika	0
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Trojek, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	České vysoké učení technické v Praze / Fakulta jaderná a fyzikálně inženýrská
http://linked.open...dnocenehoVysledku	126688
http://linked.open...ai/riv/idVysledku	RIV/68407700:21340/12:00197495
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cornea; lysyl oxidase; keratoconus; immunohistochemistry; keratocytes; culture; enzyme activity (en)
http://linked.open.../riv/klicoveSlovo	enzyme activity keratocytes lysyl oxidase culture immunohistochemistry keratoconus cornea
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[84F87C113D0E]
http://linked.open...i/riv/nazevZdroje	Experimental Eye Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Identification and characterization of a novel gene causing corneal endothelial dystrophies
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	104
http://linked.open...iv/tvurceVysledku	Trojek, Tomáš Dudakova, L. Jirsova, K. Kalasova, S. Liskova, P. Palos, M.
http://linked.open...ain/vavai/riv/wos	000311133400009
http://linked.open...n/vavai/riv/zamer	Application of radionuclides and ionising radiation
issn	0014-4835
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.exer.2012.09.005
http://localhost/t...ganizacniJednotka	21340
is http://linked.open...avai/riv/vysledek of	Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas

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