About: Multiple-Input Cultivation Model Based Optimization of Penicillin Production

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Description	Unlike prevailing contemporary approach considering the influx feed flow as the only crucial input influencing the final product concentration in bioprocess cultivation, the current paper considers other (non-nutritional) inputs as well. Among them, the volume withdrawal is an important option. Two types of control strategies employing this second input are considered here, each of them using it in a different way. First, the so-called quasi-double-input strategies exploit the broth withdrawal to follow a pre-determined volume profile. Second, the true-double-input strategies consider the second input as a completely independent optimization variable. Main analysis tool here is the gradient optimization numerical algorithm and its adaptations. All resulting strategies are summarized and formulated in the context of optimization, those introduced earlier (i.e., the quasi-double-input) are unified into a common general strategy. Practical complication (inadmissible volume decrease) related to withdrawal introduction is successfully addressed and the summary results show indisputable improvement gained by the non-nutrient input introduction. Unlike prevailing contemporary approach considering the influx feed flow as the only crucial input influencing the final product concentration in bioprocess cultivation, the current paper considers other (non-nutritional) inputs as well. Among them, the volume withdrawal is an important option. Two types of control strategies employing this second input are considered here, each of them using it in a different way. First, the so-called quasi-double-input strategies exploit the broth withdrawal to follow a pre-determined volume profile. Second, the true-double-input strategies consider the second input as a completely independent optimization variable. Main analysis tool here is the gradient optimization numerical algorithm and its adaptations. All resulting strategies are summarized and formulated in the context of optimization, those introduced earlier (i.e., the quasi-double-input) are unified into a common general strategy. Practical complication (inadmissible volume decrease) related to withdrawal introduction is successfully addressed and the summary results show indisputable improvement gained by the non-nutrient input introduction. (en)
Title	Multiple-Input Cultivation Model Based Optimization of Penicillin Production Multiple-Input Cultivation Model Based Optimization of Penicillin Production (en)
skos:prefLabel	Multiple-Input Cultivation Model Based Optimization of Penicillin Production Multiple-Input Cultivation Model Based Optimization of Penicillin Production (en)
skos:notation	RIV/68407700:21230/12:00198794!RIV13-MSM-21230___
http://linked.open...avai/predkladatel	Fakulta elektrotechnická
http://linked.open...avai/riv/aktivita	P V
http://linked.open...avai/riv/aktivity	P(GAP103/12/1794), V
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Čelikovský, Sergej Pčolka, Matej
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	České vysoké učení technické v Praze / Fakulta elektrotechnická
http://linked.open...dnocenehoVysledku	152448
http://linked.open...ai/riv/idVysledku	RIV/68407700:21230/12:00198794
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nonlinear systems; optimal control; optimization (en)
http://linked.open.../riv/klicoveSlovo	nonlinear systems optimal control optimization
http://linked.open...ontrolniKodProRIV	[95C829F402AE]
http://linked.open...v/mistoKonaniAkce	Wailea, Maui, Hawaii
http://linked.open...i/riv/mistoVydani	Piscataway
http://linked.open...i/riv/nazevZdroje	Proceedings of the 51st IEEE Conference on Decision and Control
http://linked.open...in/vavai/riv/obor	BC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Advanced methods for complex systems analysis and control.
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Čelikovský, Sergej Pčolka, Matej
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2012-12-10 (xsd:date)
number of pages	6 (xsd:int)
http://purl.org/ne...btex#hasPublisher	IEEE
https://schema.org/isbn	978-1-4673-2064-1
http://localhost/t...ganizacniJednotka	21230
is http://linked.open...avai/riv/vysledek of	Multiple-Input Cultivation Model Based Optimization of Penicillin Production

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