| Attributes | Values |
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| rdf:type
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| rdfs:seeAlso
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| Description
| - The South African Bone Marrow Registry (SABMR) has a number of donors from other African countries on its database as patients come from all parts of Africa to seek medical treatment in South Africa. In December 2009, we were approached by DKMS Americas regarding a patient in the USA, originally from Nigeria, who was not able to find a matching unrelated donor anywhere in the worlds. DKMS Americas agreed to assist the patient by holding a donor drive in Nigeria. However, they needed to find a host registry for these persons and after discussion with our Medical Director, it was agreed that we would help. The reason for approaching the SABMR is that we are the only functional Registry in Africa. The donors completed SABMR application forms. The Nigerian file contains 274 healthy individuals that were typed by SBT on A*, B*, C* and DRB1* in an EFI accredited laboratory. Resolution of typing was at least intermediate (multiple-allele-codes or high resolution codes). Although the file might not fully represent the Nigerian population, it is the biggest and best-typed sample of Nigerian HLA data to date. Haplotypes were estimated by maximum likelihood approach and Expectation-Maximalization (EM) algorithm. Multiple-allele-codes were expanded to all possible alleles according to current HLA nomenclature. Results were compared to Afro-American (AFA) population. Differences were observed mainly in B-C high-resolution haplotypes. Six of the top 10 most common B-C haplotypes were not present in the AFA population (1. B*53:01-C*04:10, 2. B*53:01-C*04:06, 5. B*15:28-C*02:10, 6. B*44:03-C*04:06, 9. B*53:01-C*04:04 and 10. B*57:03-C*07:21 ).
- The South African Bone Marrow Registry (SABMR) has a number of donors from other African countries on its database as patients come from all parts of Africa to seek medical treatment in South Africa. In December 2009, we were approached by DKMS Americas regarding a patient in the USA, originally from Nigeria, who was not able to find a matching unrelated donor anywhere in the worlds. DKMS Americas agreed to assist the patient by holding a donor drive in Nigeria. However, they needed to find a host registry for these persons and after discussion with our Medical Director, it was agreed that we would help. The reason for approaching the SABMR is that we are the only functional Registry in Africa. The donors completed SABMR application forms. The Nigerian file contains 274 healthy individuals that were typed by SBT on A*, B*, C* and DRB1* in an EFI accredited laboratory. Resolution of typing was at least intermediate (multiple-allele-codes or high resolution codes). Although the file might not fully represent the Nigerian population, it is the biggest and best-typed sample of Nigerian HLA data to date. Haplotypes were estimated by maximum likelihood approach and Expectation-Maximalization (EM) algorithm. Multiple-allele-codes were expanded to all possible alleles according to current HLA nomenclature. Results were compared to Afro-American (AFA) population. Differences were observed mainly in B-C high-resolution haplotypes. Six of the top 10 most common B-C haplotypes were not present in the AFA population (1. B*53:01-C*04:10, 2. B*53:01-C*04:06, 5. B*15:28-C*02:10, 6. B*44:03-C*04:06, 9. B*53:01-C*04:04 and 10. B*57:03-C*07:21 ). (en)
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| Title
| - HLA Study in Nigeria
- HLA Study in Nigeria (en)
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| skos:prefLabel
| - HLA Study in Nigeria
- HLA Study in Nigeria (en)
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| skos:notation
| - RIV/68407700:21230/11:00194373!RIV13-MSM-21230___
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| http://linked.open...avai/predkladatel
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68407700:21230/11:00194373
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Nigeria; HLA; Haplotypes (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Borrill, V.
- Du Toit, E.
- Raffoux, C.
- Schlaphoff, T.
- Steiner, David
|
| http://localhost/t...ganizacniJednotka
| |
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