About: Tissue Morphology and Cell Impedance Based Biosensors for Toxicity Testing

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In vitro neurotoxicity testing and toxicity effect quantification plays an important role in many disciplines of biomedicine as an alternative to in vivo methods. The principle of the majority of in vitro methods corresponds to the basic concept of biosensors, i.e. measured quantity is by means of biological sensing element transformed to physical quantity easily measurable by electrical methods of measurement. Two types of biosensors suitable for neurotoxicity measurements are described in the paper. A common feature for both types is application of a living organism as biological sensing element. In the first type of biosensor the morphology of cell is evaluated using image processing methods known as videometry. In the second type of biosensors the electrical impedance of cells using an improved version of the ECIS method is a measure of toxicity effects. The results of experiments using videometry and a proposal for improvements of ECIS based biosensors are included in the paper. In vitro neurotoxicity testing and toxicity effect quantification plays an important role in many disciplines of biomedicine as an alternative to in vivo methods. The principle of the majority of in vitro methods corresponds to the basic concept of biosensors, i.e. measured quantity is by means of biological sensing element transformed to physical quantity easily measurable by electrical methods of measurement. Two types of biosensors suitable for neurotoxicity measurements are described in the paper. A common feature for both types is application of a living organism as biological sensing element. In the first type of biosensor the morphology of cell is evaluated using image processing methods known as videometry. In the second type of biosensors the electrical impedance of cells using an improved version of the ECIS method is a measure of toxicity effects. The results of experiments using videometry and a proposal for improvements of ECIS based biosensors are included in the paper. (en)
Title	Tissue Morphology and Cell Impedance Based Biosensors for Toxicity Testing Tissue Morphology and Cell Impedance Based Biosensors for Toxicity Testing (en)
skos:prefLabel	Tissue Morphology and Cell Impedance Based Biosensors for Toxicity Testing Tissue Morphology and Cell Impedance Based Biosensors for Toxicity Testing (en)
skos:notation	RIV/68407700:21230/09:00163738!RIV10-MSM-21230___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6840770012)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Ďaďo, Stanislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	České vysoké učení technické v Praze / Fakulta elektrotechnická
http://linked.open...dnocenehoVysledku	346397
http://linked.open...ai/riv/idVysledku	RIV/68407700:21230/09:00163738
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	neurotoxicity testing; biosensors; impedance of cells; ECIS method (en)
http://linked.open.../riv/klicoveSlovo	biosensors ECIS method impedance of cells neurotoxicity testing
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[EF1898E5720B]
http://linked.open...i/riv/nazevZdroje	Measurement Science Review
http://linked.open...in/vavai/riv/obor	JB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Ďaďo, Stanislav
http://linked.open...ain/vavai/riv/wos	000270990800005
http://linked.open...n/vavai/riv/zamer	Transdisciplinární výzkum v oblasti biomedicínského inženýrství II
issn	1335-8871
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	21230
is http://linked.open...avai/riv/vysledek of	Tissue Morphology and Cell Impedance Based Biosensors for Toxicity Testing Tissue Morphology and Cell Impedance Based Biosensors for Toxicity Testing Tissue Morphology and Cell Impedance Based Biosensors for Toxicity Testing Tissue Morphology and Cell Impedance Based Biosensors for Toxicity Testing

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