About: Nanomechanics of magnetically driven cellular endocytosis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Being essential for many pharmacodynamic and pharmacokinetic processes and playing a crucial role in regulating substrate detachment that enables cellular locomotion, endocytotic mechanisms in many aspects still remain a mystery and therefore can hardly be controlled. Here, we report on experimental and modeling studies of the magnetically assisted endocytosis of functionalized superparamagnetic iron oxide nanoparticles by prostate cancer cells (PC-3) and characterize the time and force scales of the cellular uptake machinery. The results indicate how the cellular uptake rate could be controlled by applied magnetic field, membrane elasticity, and nanoparticle magnetic moment. Being essential for many pharmacodynamic and pharmacokinetic processes and playing a crucial role in regulating substrate detachment that enables cellular locomotion, endocytotic mechanisms in many aspects still remain a mystery and therefore can hardly be controlled. Here, we report on experimental and modeling studies of the magnetically assisted endocytosis of functionalized superparamagnetic iron oxide nanoparticles by prostate cancer cells (PC-3) and characterize the time and force scales of the cellular uptake machinery. The results indicate how the cellular uptake rate could be controlled by applied magnetic field, membrane elasticity, and nanoparticle magnetic moment. (en)
Title	Nanomechanics of magnetically driven cellular endocytosis Nanomechanics of magnetically driven cellular endocytosis (en)
skos:prefLabel	Nanomechanics of magnetically driven cellular endocytosis Nanomechanics of magnetically driven cellular endocytosis (en)
skos:notation	RIV/68378271:_____/11:00367265!RIV12-AV0-68378271
http://linked.open...avai/predkladatel	Fyzikální ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M06002), P(KAN301370701), Z(AV0Z10100522)
http://linked.open...iv/cisloPeriodika	18
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Zablotskyy, Vitaliy A. Jastrabík, Lubomír Dejneka, Alexandr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	214788
http://linked.open...ai/riv/idVysledku	RIV/68378271:_____/11:00367265
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	magnetically controled endocytosis; cell membranes; iron oxide nanoparticles (en)
http://linked.open.../riv/klicoveSlovo	iron oxide nanoparticles cell membranes magnetically controled endocytosis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[C44B0371A838]
http://linked.open...i/riv/nazevZdroje	Applied Physics Letters
http://linked.open...in/vavai/riv/obor	BM
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Optical structures, detection systems and relevant technologies for low photon number applications Nanostructured Macroscopic Systems - Technology and Characterisation
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	99
http://linked.open...iv/tvurceVysledku	Dejneka, Alexandr Jastrabík, Lubomír Zablotskyy, Vitaliy A. Lunov, O. Polyakova, T. Simmet, T. Syrovets, T.
http://linked.open...ain/vavai/riv/wos	000296659400100
http://linked.open...n/vavai/riv/zamer	Wave and Corpuscular Light Propagation, Optical Materials and Technology
issn	0003-6951
number of pages	3 (xsd:int)
http://bibframe.org/vocab/doi	10.1063/1.3656020
is http://linked.open...avai/riv/vysledek of	Nanomechanics of magnetically driven cellular endocytosis Nanomechanics of magnetically driven cellular endocytosis

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