About: Metallochelating liposomes with associated lipophilised norAbuMDP as biocompatible platform for construction of vaccines with recombinant His-tagged 3 antigens: Preparation, structural study and immune response towards rHsp90

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About: Metallochelating liposomes with associated lipophilised norAbuMDP as biocompatible platform for construction of vaccines with recombinant His-tagged 3 antigens: Preparation, structural study and immune response towards rHsp90 Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Hsp90-CA is present in cell wall of Candida pseudohyphae or hyphae - typical pathogenic morphotype for 31 both systemic and mucosal Candida infections. Heat shock protein from Candida albicans (hsp90-CA) is an 32 important target for protective antibodies during disseminated candidiasis of experimental mice and human. 33 His-tagged protein rHsp90 was prepared and used as the antigen for preparation of experimental 34 recombinant liposomal vaccine. Nickel-chelating liposomes (the size around 100 nm, PDI0.1) were 35 prepared from the mixture of egg phosphatidyl choline and nickel-chelating lipid DOGS-NTA-Ni (molar ratio 36 95:5%) by hydration of lipid film and extrusion methods. New non-pyrogenic hydrophobised derivative of 37 MDP (C18-O-6-norAbuMDP) was incorporated into liposomes as adjuvans. by metallochelating bond and the structure of these proteoliposomes 39 was studied by dynamic light scattering, AF microscopy, TEM and GPC. Hsp90-CA is present in cell wall of Candida pseudohyphae or hyphae - typical pathogenic morphotype for 31 both systemic and mucosal Candida infections. Heat shock protein from Candida albicans (hsp90-CA) is an 32 important target for protective antibodies during disseminated candidiasis of experimental mice and human. 33 His-tagged protein rHsp90 was prepared and used as the antigen for preparation of experimental 34 recombinant liposomal vaccine. Nickel-chelating liposomes (the size around 100 nm, PDI0.1) were 35 prepared from the mixture of egg phosphatidyl choline and nickel-chelating lipid DOGS-NTA-Ni (molar ratio 36 95:5%) by hydration of lipid film and extrusion methods. New non-pyrogenic hydrophobised derivative of 37 MDP (C18-O-6-norAbuMDP) was incorporated into liposomes as adjuvans. by metallochelating bond and the structure of these proteoliposomes 39 was studied by dynamic light scattering, AF microscopy, TEM and GPC. (en)
Title	Metallochelating liposomes with associated lipophilised norAbuMDP as biocompatible platform for construction of vaccines with recombinant His-tagged 3 antigens: Preparation, structural study and immune response towards rHsp90 Metallochelating liposomes with associated lipophilised norAbuMDP as biocompatible platform for construction of vaccines with recombinant His-tagged 3 antigens: Preparation, structural study and immune response towards rHsp90 (en)
skos:prefLabel	Metallochelating liposomes with associated lipophilised norAbuMDP as biocompatible platform for construction of vaccines with recombinant His-tagged 3 antigens: Preparation, structural study and immune response towards rHsp90 Metallochelating liposomes with associated lipophilised norAbuMDP as biocompatible platform for construction of vaccines with recombinant His-tagged 3 antigens: Preparation, structural study and immune response towards rHsp90 (en)
skos:notation	RIV/68378271:_____/11:00361499!RIV12-AV0-68378271
http://linked.open...avai/predkladatel	Fyzikální ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06058), P(GAP304/10/1951), P(KAN200100801), P(KAN200520703), Z(AV0Z10100520), Z(AV0Z40550506), Z(MSM6198959223), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kratochvílová, Irena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	211711
http://linked.open...ai/riv/idVysledku	RIV/68378271:_____/11:00361499
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	recombinant vaccine; liposome (en)
http://linked.open.../riv/klicoveSlovo	liposome recombinant vaccine
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[8529AA245F05]
http://linked.open...i/riv/nazevZdroje	Journal of Controlled Release
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	22 (xsd:int)
http://linked.open...vavai/riv/projekt	The use of ultrasound in nanomedicine Bioactive Biocompatible Surfaces and Novel Nanostructured Composites for Applications to Medicine and Drug Delivery Nanoliposomes for development of recombinant vaccines and targetted immunotherapeutics Safer biotechnology of the allogeneic hematopoietic stem cells in solid and hematological cancer as an adoptive immunotherapy
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	151
http://linked.open...iv/tvurceVysledku	Kratochvílová, Irena Šebela, M. Ledvina, Miroslav Bartheldyová, E. Czerneková, L. Horynová, M. Korvasová, Z. Koudelka, Š. Kulich, P. Křupka, M. Mašek, J. Michálek, J. Miller, A. D. Plocková, J. Raška, M. Turánek, J. Turánek-Knotigová, P. Vrbová, J. Zachová, K. Zyka, Daniel Škodová, P. Škrabalová, M.
http://linked.open...ain/vavai/riv/wos	000291845600012
http://linked.open...n/vavai/riv/zamer	Specific effects in condensed systems with reduced dimension and broken symmetry Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Nové možnosti diagnostiky a imunomodulace u infekčních onemocnění a imunopatologických stavů Animal disease research, prevention and food chain protection
issn	0168-3659
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jconrel.2011.01.016
is http://linked.open...avai/riv/vysledek of	Metallochelating liposomes with associated lipophilised norAbuMDP as biocompatible platform for construction of vaccines with recombinant His-tagged 3 antigens: Preparation, structural study and immune response towards rHsp90 Metallochelating liposomes with associated lipophilised norAbuMDP as biocompatible platform for construction of vaccines with recombinant His-tagged 3 antigens: Preparation, structural study and immune response towards rHsp90

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