About: MicroRNA Editing Facilitates Immune Elimination of HCMV Infected Cells

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About: MicroRNA Editing Facilitates Immune Elimination of HCMV Infected Cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The human cytomegalovirus (HCMV) is extremely prevalent in the human population. Infection by HCMV is life threatening in immune compromised individuals and in immune competent individuals it can cause severe birth defects, developmental retardation and is even associated with tumor development. While numerous mechanisms were developed by HCMV to interfere with immune cell activity, much less is known about cellular mechanisms that operate in response to HCMV infection. Here we demonstrate that in response to HCMV infection, the expression of the short form of the RNA editing enzyme ADAR1 (ADAR1-p110) is induced. We identified the specific promoter region responsible for this induction and we show that ADAR1-p110 can edit miR-376a. Accordingly, we demonstrate that the levels of the edited-miR-376a (miR-376a(e)) increase during HCMV infection. Importantly, we show that miR-376a(e) downregulates the immune modulating molecule HLA-E and that this consequently renders HCMV infected cells susceptible to elimination by NK cells. The human cytomegalovirus (HCMV) is extremely prevalent in the human population. Infection by HCMV is life threatening in immune compromised individuals and in immune competent individuals it can cause severe birth defects, developmental retardation and is even associated with tumor development. While numerous mechanisms were developed by HCMV to interfere with immune cell activity, much less is known about cellular mechanisms that operate in response to HCMV infection. Here we demonstrate that in response to HCMV infection, the expression of the short form of the RNA editing enzyme ADAR1 (ADAR1-p110) is induced. We identified the specific promoter region responsible for this induction and we show that ADAR1-p110 can edit miR-376a. Accordingly, we demonstrate that the levels of the edited-miR-376a (miR-376a(e)) increase during HCMV infection. Importantly, we show that miR-376a(e) downregulates the immune modulating molecule HLA-E and that this consequently renders HCMV infected cells susceptible to elimination by NK cells. (en)
Title	MicroRNA Editing Facilitates Immune Elimination of HCMV Infected Cells MicroRNA Editing Facilitates Immune Elimination of HCMV Infected Cells (en)
skos:prefLabel	MicroRNA Editing Facilitates Immune Elimination of HCMV Infected Cells MicroRNA Editing Facilitates Immune Elimination of HCMV Infected Cells (en)
skos:notation	RIV/68378050:_____/14:00435784!RIV15-AV0-68378050
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Hořejší, Václav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	29206
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/14:00435784
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HCMV; miRNA; HLA-E (en)
http://linked.open.../riv/klicoveSlovo	HLA-E miRNA HCMV
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3FC2D1D8DCD7]
http://linked.open...i/riv/nazevZdroje	Plos Pathogens
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Hořejší, Václav Shomron, N. Dijan, E. Galun, E. Hengel, H. Isakov, O. Le, V.T.K. Livneh, Y. Mandelboim, O. Nachmani, D. Weisblum, Y. Wolf, D. G. Zimmermann, A.
http://linked.open...ain/vavai/riv/wos	000332085900029
issn	1553-7374
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.ppat.1003963

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