About: Structures of human cytosolic and mitochondrial nucleotidases: implications for structure-based design of selective inhibitors

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The human 5'(3')-deoxyribonucleotidases catalyze the dephosphorylation of deoxyribonucleoside monophosphates to the corresponding deoxyribonucleosides and thus help to maintain the balance between pools of nucleosides and nucleotides. Here, the structures of human cytosolic odeoxyribonucleotidase (cdN) at atomic resolution (1.08 angstrom) and mitochondrial deoxyribonucleotidase (mdN) at near-atomic resolution (1.4 angstrom) are reported. The attainment of an atomic resolution structure allowed interatomic distances to be used to assess the probable protonation state of the phosphate anion and the side chains in the enzyme active site. A detailed comparison of the cdN and mdN active sites allowed the design of a cdN-specific inhibitor. The human 5'(3')-deoxyribonucleotidases catalyze the dephosphorylation of deoxyribonucleoside monophosphates to the corresponding deoxyribonucleosides and thus help to maintain the balance between pools of nucleosides and nucleotides. Here, the structures of human cytosolic odeoxyribonucleotidase (cdN) at atomic resolution (1.08 angstrom) and mitochondrial deoxyribonucleotidase (mdN) at near-atomic resolution (1.4 angstrom) are reported. The attainment of an atomic resolution structure allowed interatomic distances to be used to assess the probable protonation state of the phosphate anion and the side chains in the enzyme active site. A detailed comparison of the cdN and mdN active sites allowed the design of a cdN-specific inhibitor. (en)
Title	Structures of human cytosolic and mitochondrial nucleotidases: implications for structure-based design of selective inhibitors Structures of human cytosolic and mitochondrial nucleotidases: implications for structure-based design of selective inhibitors (en)
skos:prefLabel	Structures of human cytosolic and mitochondrial nucleotidases: implications for structure-based design of selective inhibitors Structures of human cytosolic and mitochondrial nucleotidases: implications for structure-based design of selective inhibitors (en)
skos:notation	RIV/68378050:_____/14:00435088!RIV15-GA0-68378050
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GA203/09/0820)
http://linked.open...iv/cisloPeriodika	February
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Pachl, Petr Brynda, Jiří Fábry, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	47958
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/14:00435088
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	5(3)-deoxyribonucleotidases; enzyme inhibition; hydrolases; structure-based drug design (en)
http://linked.open.../riv/klicoveSlovo	enzyme inhibition structure-based drug design 5(3)-deoxyribonucleotidases hydrolases
http://linked.open...odStatuVydavatele	DK - Dánské království
http://linked.open...ontrolniKodProRIV	[2AD35902E937]
http://linked.open...i/riv/nazevZdroje	Acta Crystallographica Section D-Biological Crystallography
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Structure based drug design of specific nucleotidases inhibitors, potentially pharmacologically important compounds.
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	70
http://linked.open...iv/tvurceVysledku	Brynda, Jiří Fábry, Milan Pachl, Petr Rosenberg, Ivan Řezáčová, Pavlína Šimák, Ondřej
http://linked.open...ain/vavai/riv/wos	000331554500025
issn	0907-4449
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1107/S1399004713030502

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